TY - JOUR T1 - The Effect of Interval Training and Consuming Fenugreek Seed Extract on FGF-21 and VEGF Gene Expression in Patients With Coronary Artery Diseases TT - ﺗﺄﺛﯿﺮ ﺗﻤﺮیﻦ دوره‌ای و ﻣﺼﺮف ﻋﺼﺎره داﻧﻪ ﺷﻨﺒﻠﯿﻠﻪ ﺑﺮ ﺑﯿﺎن ژن FGF-21 و VEGF در ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﺑﯿﻤﺎری ﻋﺮوق ﮐﺮوﻧﺮ JF - QHMS JO - QHMS VL - 27 IS - 2 UR - http://imtj.gmu.ac.ir/article-1-3583-en.html Y1 - 2021 SP - 130 EP - 147 KW - Interval training KW - Fenugreek KW - Fibroblast Growth Factor (FGF21) KW - Vascular Endothelial Growth Factor (VEGF) KW - Coronary artery disease N2 - Aims: A high-fat diet, smoking, and a sedentary lifestyle are the major causes of Coronary Artery Disease (CAD). This study aimed to explore the effect of interval training and the consumption of fenugreek seed extract on FGF-21 and VEGF gene expression among patients with CAD. Methods & Materials: The present quasi-experimental study was conducted on a sample of 32 male patients with CAD, aged between 55 and 65 years. They were randomly divided into four groups: control, training only, fenugreek only, and training + fenugreek. The training program consisted of eight weeks of interval running, three sessions per week with an intensity of 55% and 65% of heart rate reserve, with a gradually increasing intensity. Subjects consumed 10 mg/kg of fenugreek extract daily. Real-time PCR was used to measure the expression of FGF-21 and VEGF genes. Findings: The results showed that the mean expression ratios of FGF-21 in training only, fenugreek only, and training + fenugreek groups were significantly higher than the control group (P<0.0001). The fenugreek + training group had a greater significant increase (P<0.0001) more than the training + fenugreek group. Moreover, the mean Coefficient of Variation (CV) of VEGF gene expression was significantly increased more than that in the training group (P<0.0001), fenugreek group (P=0.0004), and the training + fenugreek group (P<0.0001), compared to the control group. The fenugreek + training group had a greater and more significant increase than the training only (P=0.0181) and the fenugreek only groups (P<0.0495). Conclusion: The results showed that a combination of interval training and consumption of fenugreek seed extract increased the CV of FGF-21 and VEGF gene expression and thus, have beneficial effects on the angiogenesis pathway in patients with CADs. M3 10.32598/hms.27.2.3456.1 ER -