TY - JOUR T1 - Simultaneous Effect of High-Intensity Interval Training (HIIT) and Consumption of Flaxseed on Serum Levels of TNF-α and IL1β in Rats TT - تاثیر همزمان تمرین تناوبی شدید و مصرف روغن بذر کتان بر سطوح سرمی TNF-α و IL-1 β در موش‌های صحرایی JF - QHMS JO - QHMS VL - 23 IS - 4 UR - http://imtj.gmu.ac.ir/article-1-2636-en.html Y1 - 2017 SP - 257 EP - 263 KW - High-Intensity Interval Training [https://www.ncbi.nlm.nih.gov/mesh/2016768] KW - Flaxseed Oil [https://www.ncbi.nlm.nih.gov/mesh/68008043] KW - TNF-α [https://www.ncbi.nlm.nih.gov/mesh/68014409] KW - IL-1β [https://www.ncbi.nlm.nih.gov/mesh/68053583] N2 - Aims: The high concentration of Interleukin-1 beta (IL-1β) and Tumor Necrosis Factor- α (TNF-α) is an important risk factor for developing cardiovascular disease. The purpose of this study was to investigate the simultaneous effect of High-Intensity Interval Training (HIIT) and the use of flaxseed oil with different doses on the serum levels of TNF-α and IL1β in rats. Materials & Methods: In this experimental study, 30 Wistar rats were randomly divided into six groups: control, training, 10mg/kg supplement, 30mg/kg supplement, training with 10mg/kg supplement and training with 30mg/kg supplement. The groups performed High-Intensity Interval Training (HIIT) for 10 weeks and received flaxseed oil extracts. Data were analyzed by one way ANOVA and LSD post hoc test. Findings: Serum levels of IL1β in the training group and training groups with doses of 10 and 30mg/kg of extract were significantly lower than the control group. Serum levels of IL1β in the training group with 30mg/kg of extract, was significantly lower than group with 10mg/kg of extract. Also, serum levels of TNF-α in the training group, training groups with doses of 10 and 30mg/kg of extract and group with 30mg/kg of extract were significantly lower than the control group. Serum levels of TNF-α in the training group with 30mg/kg of extract were significantly lower than other groups (p<0.05). Conclusion: High-Intensity Interval Training (HIIT) and consumption of flaxseed oil for 10 weeks have interactive effects on reduction of serum levels of TNF-α and IL-1β in rats. M3 ER -