TY - JOUR T1 - The status of E-cadherin expression in papillary thyroid carcinoma and it’s relationship with prognostic factors TT - بررسی ارتباط بین بیان پروتئین E-cadherin در کارسینوم پاپیلری تیروئید با برخی عوامل مؤثر بر پیش‌آگهی آن JF - QHMS JO - QHMS VL - 19 IS - 4 UR - http://imtj.gmu.ac.ir/article-1-1728-en.html Y1 - 2014 SP - 192 EP - 196 KW - Prognosis KW - Cadherinz KW - Papillary Carcinoma Thyroid N2 - Aims: Thyroid cancer is the most common endocrine malignancy and papillary carcinoma is the most common thyroid cancer. There are different biologic markers which are used for prognosis determination one of which is a cell binding molecule, E-cadherin. . The purpose of this study was to determine the frequency of E-cadherin expression in papillary thyroid cancer and its relation with gender, tumor size, and lymph nodes involvement. Methods: This study was performed on 73 tissue samples from patients with papillary thyroid cancer who referred to Mostafa Khomeini Hospital in Tehran, Iran (2005- 2008). The method of staining for determination of E-cadherin expression was immunohistochemistry. We evaluated the size of tumor, lymph nodes involvement, and their relation with E-cadherin expression. Results: The mean age was 41.85± 16.65 years. 67% of samples were positive for E-cadherin and 21.9% had lymph nodes involvement. The mean size of patients’ tumor was 3.86± 2.38 cm. There was not any significant relationship between E-cadherin expression and tumor size and gender but there was a significant and reverse relationship between E-cadherin expression and lymph nodes involvement (P M3 ER -