RT - Journal Article T1 - Antinociceptive Effects of Hydroalcoholic Extract of Lactuca Sativa Longifolia Leaves in Male Mice JF - QHMS YR - 2010 JO - QHMS VO - 16 IS - 2 UR - http://imtj.gmu.ac.ir/article-1-894-en.html SP - 5 EP - 11 K1 - Antinociception K1 - formalin test K1 - lactuca sativa longifolia K1 - male mice K1 - tailflick AB -   Background and Aim: Nowadays, We have focused our attention to herbal medicines because of their side effects and expensiveness of chemical drugs . In this research, we evaluated antinociceptive effects of hydroalcoholic extract of L actuca sativa longifolia leaves using tail-flick and formalin test in male mice.   Materials and Methods: We evaluated antinociceptive effects of hydroalcoholic exract of L actuca sativa longifolia leaves at doses of 85, 165,330,660 and 1300 mg/kg. All injections were administered intraperitoneally. Sham group received normal saline and Morphine group (1 mg/ kg i.p.) was used as positive control. The possible mechanisms of antinociceptive action of the extract were also investigated by pretreatment with Naloxane (1mg/kg i.p.) .   Results: Hydroalcoholic extract of L actuca sativa longifolia leaves exhibited significant antinociceptive activity at doses of 165,330,660 and 1300 mg/kg in tail flick test, and maximal inhibitions were observed at doses of 660 and 1300 mg/kg (P LA eng UL http://imtj.gmu.ac.ir/article-1-894-en.html M3 ER -