@ARTICLE{Hosseini, author = {Hosseini, A. and Shariatifar, N. and }, title = {Effects of methanolic extract of Echium amoenum Fisch & Mey on seizure induced by picrotoxin in mice}, volume = {10}, number = {2}, abstract ={Background and Aim: The sedative effects of medicinal herbs of Echium Amoenum Fisch & Mey on nervous system have been known for many years. The aim of this study was to investigate the effects of methanolice extract of Echium amoenum Fisch & Mey against seizure induced by picrotoxin in mice. Materials and Methods: In this experiment study, in the first phase four groups of animals were pretreated by metabolic extract of this plant via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10mg/kg for the induction of seizure. Then lateney of onset time for the beginning of seizure, duration of seizure and mortality were determined. Data were subjected to the t test and chi-square test (P }, URL = {http://imtj.gmu.ac.ir/article-1-264-en.html}, eprint = {http://imtj.gmu.ac.ir/article-1-264-en.doc}, journal = {Internal Medicine Today}, doi = {}, year = {2004} }