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Volume 12, Issue 3 (vol-3 2006)                   Intern Med Today 2006, 12(3): 50-54 | Back to browse issues page

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Saghirzadeh M, Mohammadi S, Ghiassi Nejad M, Hayata I. Premature centromere separation of chromosomes in a woman being exposed to high-level natural radiation. Intern Med Today 2006; 12 (3) :50-54
URL: http://imtj.gmu.ac.ir/article-1-63-en.html
Premature centromere separation of chromosomes in a woman being exposed to high-level natural radiation
M. Saghirzadeh , Sh. Mohammadi , M. Ghiassi Nejad * 1, I. Hayata
1- , ghiasi_m@modares.ac.ir
Abstract:   (13451 Views)
Abstract In a cytogenetic study on the residents in the high level natural radiation areas of Ramsar, a woman had an acentric like C group chromosome showing the premature centromere separation in the peripheral lymphocytes. This unusual chromosome was identified as an X chromosome with Fluorescent In situ Hybridization (FISH) method. Analysis of the 2038 cells revealed that these unusual X chromosomes had ability to replicate. This replication was associated with non-disjunction leading to aneuploid cells. In this paper, induction of the premature centromere separation (PCS) in the aged women is discussed in relation to the effect of the chronic exposure to low dose.
Keywords: Premature centromere separation; Chromosome aberrations; High-level natural radiation areas
Full-Text [DOC 317 kb]   (5570 Downloads)    
Type of Study: Original | Subject: Basic Medical Science
Received: 2007/07/14 | Published: 2006/09/15
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