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Volume 25, Issue 3 (Summer 2019)                   Intern Med Today 2019, 25(3): 146-157 | Back to browse issues page


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Kazemi A, Mahalati S. Effects of 10-Week Concurrent Training on Insulin Resistance and the Serum Levels of Vaspin and Visfatin in Overweight Females. Intern Med Today 2019; 25 (3) :146-157
URL: http://imtj.gmu.ac.ir/article-1-3057-en.html
1- Department of Physical Education and Sports Sciences, Faculty of Literature & Humanities, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran. , RKAZEMI22@YAHOO.COM
2- Department of Physical Education and Sports Sciences, Faculty of Literature & Humanities, Kerman Branch, Islamic Azad University, Kerman , Iran.
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1. Introduction
verweight and obesity in children and adolescents are closely linked to cardiovascular disease, asthma, mental disorders, hypertension, and lipid disorders. The prevalence of obesity and overweight has increased in adolescents, especially among females. Moreover, the release of adipokines by adipose tissue may affect insulin resistance and sensitivity through inflammatory factors. Additionally, the potential impact of concurrent training on body composition could affect adipokines levels. Therefore, it was necessary to conduct this study. 
Barzegari and Amouzad Mahdirejei [1], and Askari et al. [2] have previously investigated this research area. The present study aimed to investigate the effects of a 10-week concurrent training on the serum levels of vaspin and visfatin in overweight females.
2. methods
This was a quasi-experimental study. The study samples were 24 overweight female students living in Kerman City, Iran, in 2016. The samples were randomly assigned to the training (n=12) and control (n=12) groups. The serum level of insulin and the blood glucose were measured by ELISA kit (Mercodia, Sweden) and calorimetric kit (Pars Azmon, Iran), respectively, and according to the manufacturers’ instructions.  Moreover, for measuring the serum levels of vaspin and visfatin, the ELISA kit (USCN Business Co.) was applied.
3. Results
The obtained data suggested that a 10-week concurrent training program significantly decreased the plasma levels of vaspin and visfatin as well as insulin resistance. The collected results revealed no significant decrease in fasting blood glucose level (Tables 1, 2 & 3).


4. Discussion
Concurrent training demonstrated a regulatory effect on vaspin levels and decreased those. Barzegari and Amouzad Mahdirejei [1] argued that an 8-week resistance training significantly reduced the plasma level of vaspin. In addition, they reported a significant decrease in cholesterol level and a significant increase in high-density lipoprotein cholesterol level. In the present study, it was also observed that performing 10 weeks of combined training significantly decreased the vaspin level. The study findings of Askari et al. were in contrast with that of the present study [2]. We conducted 10 weeks of concurrent training; however, their studied subjects completed 12 weeks of concurrent training. The data obtained from both investigations suggested the prominent role of concurrent training, compared to other exercise methods. For instance, endurance training reduced inflammatory adipokines, like vaspin and visfatin, and modulated insulin resistance [2].
It is suggested that future studies precisely evaluate the investigated variables together with their receptors in target tissues and adipokines releasing tissues in concurrent training programs. A limitation of the present study was disregarding the measurement of variables in the tissue.
5. Conclusion
Concurrent training program reduced insulin resistance by modulating the plasma levels of vaspin and visfatin in overweight females. As a result, using this type of exercise may improve sensitivity to insulin and prevent metabolic diseases.
Ethical Considerations
Compliance with ethical guidelines

This a registered clinical trial (registration code: IRCT20180708040399N2) with ethical approval (Ethical code: Ir.Kmu.rec.1394.407). All ethical principles including informed consent, confidentiality, non-invasion of privacy, protection of subjects from pressure and harm and physical and psychological hazards, were fully respected. 
Funding
This article was extracted from a Master's thesis authored by Sareh Mahalati in Physical Education and Sports Sciences approved by Faculty of Literature & Humanities at Islamic Azad University of Kerman.
Authors' contributions
Conceptualization (contribution rate= 85%), article writing (65%), formal analysis (75%) and methodology (50%) by Abdolreza Kazemi; conceptualization (contribution rate=15%), article writing (35%), formal analysis (25%) and methodology (50%) by Sareh Mahalati. 
Conflicts of interest
The authors declared no conflict of interest.
Type of Study: Original | Subject: Physiology
Received: 2018/06/23 | Accepted: 2019/04/30 | Published: 2019/09/16

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