Volume 10, Issue 3 (vol- 3 2004)                   Horizon Med Sci 2004, 10(3): 57-62 | Back to browse issues page

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Khooei A, Taghavi R, Keramati M. Juxtaglomerular cell tumor of the kidney a rare cause of hypertension cause of hypertension Case report with literature review . Horizon Med Sci. 2004; 10 (3) :57-62
URL: http://hms.gmu.ac.ir/article-1-284-en.html
1- , khooei_ar@yahoo.ca
Abstract:   (17183 Views)
Juxtaglomerular cell tumor or reninoma is an extremely rare tumor of the kidney, specially occurring in the young adults. This tumor by producing rennin and activating the Renin-Angiotansin- Aldostrone pathway causes an increase in blood pressure associated with hypokalemic metabolic alkalosis. We report a young female patient, aged 18 years, presented with hypertension, as the chief complain, and associated hypokalemia. CT-Scan and sonography showed a renal mass diagnosed as renal cell carcinoma or pheochromocytoma. In the nephrectomy specimen there was a tumor measuring 4.5*3.5 cm, creamy to brownish color limited to the renal capsule. Microscopic examination revealed an encapsulated tumor composed of sheets of round to polyhedral cells in a vascular stroma with slight atypia and without mitoses or necrosis, finally diagnosed as juxtaglomerular cell tumor. Microscopic features and clinical course are discussed with reviewing the literatures. Because of the rarity of this neoplasm we highly emphasize reninoma should always be considered as a probable cause in a young adult with hypertension.
Type of Study: Original | Subject: Internal Medicine
Received: 2008/07/28 | Published: 2004/10/15

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