Volume 10, Issue 2 (vol- 2 2004)                   Intern Med Today 2004, 10(2): 20-25 | Back to browse issues page

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Hosseini A, Shariatifar N. Effects of methanolic extract of Echium amoenum Fisch & Mey on seizure induced by picrotoxin in mice. Intern Med Today. 2004; 10 (2) :20-25
URL: http://imtj.gmu.ac.ir/article-1-264-en.html
1- , ara_hos2000@yahoo.com
Abstract:   (13124 Views)
Background and Aim: The sedative effects of medicinal herbs of Echium Amoenum Fisch & Mey on nervous system have been known for many years. The aim of this study was to investigate the effects of methanolice extract of Echium amoenum Fisch & Mey against seizure induced by picrotoxin in mice. Materials and Methods: In this experiment study, in the first phase four groups of animals were pretreated by metabolic extract of this plant via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10mg/kg for the induction of seizure. Then lateney of onset time for the beginning of seizure, duration of seizure and mortality were determined. Data were subjected to the t test and chi-square test (P<0.05). Results: The results showed that latency of seizure was increased significantly in case groups that pretreated with different doses of extract (P<0.05) (especially 6.25 mg/kg). In addition, these doses delayed significantly the time death in mice (P<0.01). Conclusion: The extract of Echium Amoenum appears to be effective on seizure induced by picrotoxin in mice.
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Type of Study: Original | Subject: Internal Medicine
Received: 2008/07/24 | Published: 2004/07/15

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