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Abstract Background and Aim: Breast cancer is a prevalent disease in the world, region and Birjand and there are racial and regional differences in the epidemiology and variations in the pattern of P53 gene mutations. We studied the prevalence of P53 gene mutations, estrogen and progesterone in breast caner patients. Materials and Methods: In this descriptive analytical study, all consecutive pathological specimens of breast cancer patients in Birjand during 2 years were examined. First the neoplasm was determined and specimen from fixed parafinated blocks was obtained. After depparafination, immunohistochemistry staining with P53, estrogen and progesterone kit (DAKO Company, Denmark) was done. Data was analyzed by chi-square test. And P0.05 was regard as significant. Results: 51 specimens examined. Most of them were olden than 48 years (54.9%), residing in urban area (62.2%) and housewife (82.4%). The specimen were positive for estrogen, progesterone and P53 receptors in 12 (23.5%), (21.6%) and 14 (27.5%) respectively. There was no significant relation between the prevalence receptor positive and age, place of residence. Housewives had less estrogen receptor compared to employed patient (14.3% vs. .66.7% P<0.001). Progesterone and P53 receptor positivists were more common in employed patient comport to housewives but it was not significant. Conclusion: According to the result of this study and high prevalence of breast cancer, more studies with more sample size should be done to help patients for better treatment and survival.

Keywords: Neoplasm; P53; Estrogen; Progesterone; Breast

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