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Aims: Growth factors are associated with a change in body composition and chronic diseases such as cancer. The aim of this study was to determine the individual and concomitant effect of water-based exercise and oral Zingiber officinale supplement on Changes in growth factors and estrogen in overweight women with breast cancer. Methods: In a semi-experimental study, Forty obese women diagnosed with breast cancer(76±9 kg, fat mass 41.8±4 percent) participated. Subjects were randomly assigned into groups placebo, water-based exercise, Zingiber and water-based exercise+Zingiber groups. Subjects in the Zingiber group and combined group orally received 4 capsules contained 750 mg of zingiber flour for 6 weeks. The water-based exercise program were collected at a progressive intensity and time, ranged from 50 to 75 percent of heart rate reserve, for 6 weeks. Fasting blood sampling was collected at the pretest and post-test. Results: Although, the Zingiber and or the water-base exercise resulted in a reduction in IGF-1 and estrogen levels and a increase in IGFBP-3 levels, changes in the index following the combined intervention (exercise in water+Ginger supplements) were more pronounced compared with pre-test and the control group. However, there was the significant difference only in IGFBP-3 levels between water-base exercise and Zingiber supplementation groups (p=0.046). Conclusion: Our findings indicate a protective effect of the nondrug strategies such as exercise in water and anti-inflammatory herbal factors in the pathogenesis of growth and metabolic responses in overweight women diagnosed with breast cancer.

Keywords: Estrogens, Exercise, Ginger, Breast Neoplasms, Receptors/Growth Factor

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