Volume 19, Issue 4 (1-2014)                   Horizon Med Sci 2014, 19(4): 236-241 | Back to browse issues page

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kalantari H, motaharitabar E, goudarzi M, rashidi nooshabadi M. The protective effect of hidroalchoholic extract Teucrium polium L against bromobenzene -induced hepatotoxicity in mice. Horizon Med Sci. 2014; 19 (4) :236-241
URL: http://hms.gmu.ac.ir/article-1-1749-en.html
1- ahvaz medica sciences
2- ahvaz medica sciences , motahari85@yahoo.com
Abstract:   (4170 Views)
Aims: Teucrium polium is used in Iranian traditional medicine for different diseases. In the present study, protective effect of Teucrium polium L. extract was investigated on bromobenzene-induced hepatotoxicity in mice. Methods: This experimental study was performed on 48 male albino mice. The animals were randomly divided into six groups. Groups 1 and 2 received normal saline and extract of Teucrium polium (500 mg/kg) orally for 10 days, respectively group 3 received bromobenzene (0.36 ml/kg, ip) only on the 10th day groups 4-6 received ethanolic extract orally in doses of 125, 250 and 500 mg/kg, respectively, during 10 days and bromobenzene (0.36 ml/kg, ip) on the 10th day 1 hour after the last dose of extract. Blood and liver samples were collected 24 hours after bromobenzene injection. Then, serum activity of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and directed and total bilirubin were measured. Finally, the biochemical findings were matched with histopathological verifications, the significance of the differences between groups was compared with one-way analysis of variance (ANOVA) followed by Tukey’s posttesting with P-values <0.05. Results: The results showed a significant increase in liver enzyme activity by bromobenzene. The treated groups with Teucrium polium showed significant decrease in liver enzyme activity in doses of 125, 250 and 500 mg/kg (p<0.05). Histological observations also confirmed the results. Conclusion: The results revealed that hydroalcoholic extract of Teucrium polium has protective effect on liver toxicity induced by bromobenzene.
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Type of Study: Applicable | Subject: Basic Medical Science
Received: 2013/04/16 | Accepted: 2014/01/1 | Published: 2014/01/1

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