Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Effect of Eight Weeks High Intensity Aerobic Trainingon Migrane Headache Indicators
133
138
FA
Abdolsamad
Abdi
Exercise Physiology Department, Physical Education & Sport Sciences Faculty, Razi University, Kermanshah, Iran
Abdolhossein
Parnow
Exercise Physiology Department, Physical Education & Sport Sciences Faculty, Razi University, Kermanshah, Iran
Mohammad
Azizi
Exercise Physiology Department, Physical Education & Sport Sciences Faculty, Razi University, Kermanshah, Iran
Abstract
Aims: Migraine is a common neurological disorder which causes numerous pain and suffering for patients. In addition to the pharmacological treatments, a non-pharmacological treatment such as exercise is recommended to prevent migraine. This study aimed to investigate the effects of high intensity aerobic training on migraine indicators in the patients.
Materials & Methods: The present semi-experimental study with one-group pretest-posttest designing was done on migraine patients of Noorabad City, Iran, using convenience sampling. 12 inactive men with migraine were participated in this study. The study was last 16 weeks. The subjects did high intensity aerobic training in 40-45min and 2 sessions in the week. 48hours after the last training session, body composition indices and aerobic endurance and 4 weeks after completion of the training program, migraine headache indices were reassessed. Statistical analysis was done using student T-test for dependent group by SPSS 19 software.
Findings: High intensity aerobic training reduced migraine headache indicators including the attacks frequency (p=0.025), severity of the attacks (p=0.024) and the duration (p=0.031) and it also improved the aerobic fitness of the subjects (p=0.001) significantly. Lipid percentage reduced 1.49% significantly (p=0.024).
Conclusion: 8 weeks of high intensity aerobic training program can reduce the migraine headache indices (migraine attack frequency, intensity and the duration).
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Effect of palm pollen extract on sexual hormone levels and follicle numbers in adult female BALB/c mice
139
143
FA
Ebrahim
hosseini
Biology Department, Sciences Faculty, Fars Science & Research Branch, Islamic Azad University, Shiraz, Iran
Davood
Mehrabani
Pathology Department, Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
fatemeSadat
Razavi
Biology Department, Sciences Faculty, Fars Science & Research Branch, Islamic Azad University, Shiraz, Iran
Aims: Using chemical drugs to treat disease often is associated with side effects. Recently, using herbal medicines, which have fewer side effects, has flourished to treat many diseases, including infertility. This study was done aimed to investigate the effect of palm pollen aqueous extract on sexual hormones and follicle cells numbers in adult female BALB/c mice.
Materials & Methods: This experimental study was done in animal house of Shiraz University of Medical Sciences in 2012. 40 adult female BALB/c mice were divided into 5 control, sham and experimental groups receiving 100, 200 and 400mg/kg of the body weight of the extract groups each with 8 members. Levels of testosterone, estrogen and progesterone were measured by radioimmunoassay and ovarian follicles numbers were counted after separation of the ovaries and sectioning and staining using Hematoxylin & Eosin by light microscopy. The results of hormonal assays were analyzed based on One-way ANOVA and Duncan's multiple range tests using SPSS 18 software.
Findings: A significant increase was observed at the level of testosterone, estrogen and progesterone compared to the control group only in the experimental group 3 (receiving 400mg/kg palm pollen extract) (p<0.01). Also, only in the experimental group 3 a significant increase was observed in the number of secondary follicles (p<0.05) and the number of antral follicles (p<0.01) compared to the control.
Conclusion: 400mg/kg palm pollen aqueous extract increases the amount of sexual hormones and secondary and antral follicle numbers in adult female mice.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Comparison of the Serum Level of β-hCG, Calcium, Phosphorus and Alkaline Phosphatase Activity between Ovarian Cancer Patients and Healthy Individuals
145
149
FA
mahnaz
Bakrani
Biochemistry Department, Biological Sciences Faculty, Fars Science & Research Branch, Islamic Azad University, Shiraz, Iran
Kahin
Shahanipour
Biochemistry Department, Biological Sciences Faculty, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Vali allah
Mehrzad
Internal Medicine Department, Medicine Faculty, Isfahan University of Medical Sciences, Isfahan, Iran
Aims: Ovarian cancer is the most common lethal malignancy female reproduction system which is diagnosed in advanced stages in the majority of cases. The main purpose of this study was to compare serum level of β-hCG tumor markers, calcium, phosphorus and alkaline phosphatase enzyme activity in healthy subjects and patients with ovarian cancer and to investigate the possibility of using these factors as markers of ovarian cancer.
Materials & Methods: This case-control study was carried out on people referring to Seyedoshohada Hospital in Isfahan and 44 women with ovarian cancer and 44 healthy women were studied from February 2012 to April 2012. β-hCG tumor marker was measured using ELISA method and serum calcium, phosphorus and alkaline phosphatase enzyme activity was measured by the photometric method. Independent T-test was used to compare studied indices between two groups.
Findings: A significant difference was observed only between β-hCG mean of patient group (2.96±1.30 units per liter) and healthy group (2.27±1.17 units per liter) (p=0.014). The mean concentration of calcium, phosphorus and alkaline phosphatase activity were not significant between patients and healthy groups (p>0.05).
Conclusion: β-hCG serum level in ovarian cancer patients undergoing chemotherapy or radiotherapy is more than healthy subjects. Also, serum level of calcium, phosphorus and alkaline phosphatase enzyme activity in ovarian cancer patients under therapy is not associated with the disease status.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Neuroprotective Effect of Alcoholic Extract of Salvia chloroleuca Against Neuronal Degeneration of Alpha Motoneurons of Anterior Horn Spinal Cord after Sciatic Nerve Injury in Rats
151
156
FA
maryam
razavi
Biology Department, Basic Sciences Faculty, Mashhad Branch, Islamic Azad University, Mashhad, Iran
maryam
Tehranipour
Biology Department, Basic Sciences Faculty, Mashhad Branch, Islamic Azad University, Mashhad, Iran
jina
Khayatzadeh
Biology Department, Basic Sciences Faculty, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Aims: Any damages to the nerve fiber blocking connection with the neurons cell body (vital cell substances synthesis part), can lead to degenerative changes in proximal and distal parts of the damaged neuron. Some plants due to the antioxidant substances are effective in the survival and division of the neurons. This study aimed to investigate the effect of alcoholic extract of Salvia chloroleuca leaves on destruction of spinal cord anterior horn alpha motoneurons after sciatic nerve injury in rats.
Materials & Methods: In this experimental study 24 male Wistar rats aged 12weeks and weighting 200-250gr were provided. The animals were divided into 4 (each=6) control, damaged, damaged + treatment with 50mg/kg alcoholic extract and damaged+treatment with 75mg/kg alcohol extract groups. To calculate the alpha motoneurons in the anterior horn of the spinal cord in the right side the dissector method was used. Data were analyzed using Minitab 13 software by independent T and ANOVA tests.
Findings: The mean density of alpha motoneurons in spinal anterior horn in control group was 1711.5±47.4, in damaged was 730.7±33.4, in damaged+treatment with 50mg/kg alcoholic extract was 1211.2±34.8 and in damaged+treatment with 75mg/kg alcoholic extract was 987.4±36.8. Mean difference between both treatment groups and damaged group was significant (p=0.001).
Conclusion: Salvia chloroleuca leaf extract increases the density of alpha motor neurons in the anterior horn of the spinal cord in rats with sciatic nerve injury, and this increase in neuronal density is associated with the intake of the extract.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Variations of Serum Electrolytes and Osmolality Levels of Athletes During One Month Fasting with Regular Physical Activity
157
163
FA
Seyed Reza
Attarzadeh Hosseini
Sport Physiology Department, Physical Education & Sports Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
Morteza
Motahari Rad
Sport Physiology Department, Physical Education & Sports Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
Keyvan
Hejazi
Sport Physiology Department, Physical Education & Sports Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
Aims: Restriction of fluid intake during Ramadan is one of the most common causes of renal dysfunction. The aim of this study was to compare the effect of one month fasting along with regular exercise on male wrestlers’ electrolytes changes and serum osmolality.
Materials & Methods: This semi-experimental study with repeated tests design was done on male wrestlers in Ramadan June and August 2014 (about 16-hour fasting). Among volunteers 9 elite and healthy wrestlers with 8 years experiences were selected using selective available and purposive sampling. Serum electrolytes and body compounds were measured 3 days before the Ramadan, 14 days after fasting and two weeks after Ramadan in the equal conditions. Data were analyzed using analysis of variance of repeated measures test.
Findings: Body weight (p=0.001) and the body water amount (p=0.037) were reduced at the end of Ramadan significantly. Urea within group mean changes (p=0.049), Creatinine (p=0.031), Uric Acid (p=0.0001) and Sodium (p=0.01) during Ramadan were increased significantly compared with the beginning of Ramadan. Serum osmolality within group changes mean (p=0.001) increased during Ramadan significantly.
Conclusion: Fasting increases serum electrolytes and osmolality in professional athletes.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Immunomodulatory Effects of 17 beta-Estradiolin NMRI Mice Immunized by SRBC
165
170
FA
Meysam
Abtahi Froushani
Microbiology Department, Veterinary Faculty, Urmia University, Urmia, Iran
hadi
esmaili gouvarchingaleh
Microbiology Department, Veterinary Faculty, Urmia University, Urmia, Iran
Bahman
mansori mothlag
Microbiology Department, Veterinary Faculty, Urmia University, Urmia, Iran
Mohammad
babaei
Microbiology Department, Veterinary Faculty, Urmia University, Urmia, Iran
Aims: Steroid hormones have powerful effect on all levels of the innate and adaptive immune systems. Among steroid hormones, estrogens play a key role in the regulation of homeostasis of bone marrow activity, cardiovascular system and central nervous system. The main purpose of this study was to determine the possible effects of moderating role of estrogen on humoral and cellular immune responses following the sheep red blood cells challenge in the mouse model.
Materials & Methods: 14 mice were divided into two groups and were immunized with SRBC antigen. The treated mice were injected with estrogen for two weeks (5mg/kg- intraperitoneally) from the beginning of the study. Specific humoral and cellular immunity, susceptibility of macrophages respiratory burst and proliferation of immune cells were measured. The Mann-Whitney test was used in order to compare using SPSS 19 software.
Findings: The 17 beta-estradiol treated mice showed a significant increase in DTH reaction. MTT test results showed an increase in the rate of lymphocyte proliferation in estrogen-treated group compared with control group. The spleen weight mean in treated mice group (28.62±1.76) showed a significant increase compared to control group (21.00±1.83) (p<0.01). The results of NBT reduction showed a decrease in spleen macrophages/monocyte respiratory burst capability.
Conclusion: It seems that 17 beta-estradiol can be considered as the moderating immune system compound.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Effect of One-Session Anaerobic Exhaustive Exercise on Lipid Profile of Active and Inactive Individuals
171
177
FA
majid
kashef
Sport Physiology Department, Physical Education Faculty, Shahid Raja’ei Teacher Training University, Tehran, Iran
sara
zare karizak
Sport Physiology Department, Physical Education Faculty, Shahid Raja’ei Teacher Training University, Tehran, Iran
meisam
shabaninia
Sport Physiology Department, Physical Education Faculty, Shooshtar Branch, Islamic Azad University, Shooshtar, Iran
Aims: Increase of harmful blood lipid levels such as low-density lipoprotein, triglyceride, total cholesterol, and reduction in the amount of beneficial lipids such as high density lipoprotein is one the most important risk factors for cardiovascular disease. The aim of this study was to compare the effects of an exhausting session of intense exercise on blood lipid profiles in active and inactive individuals.
Materials & Methods: The present semi-experimental study was done on physical education and non-physical male students of Tehran Shahid Raja’ei Teacher Training University and 20 persons were selected by purposive sampling and based on medical information. The subjects were divided into active and inactive male students. Physical activity questionnaire consisted of 16 questions to assess the level of physical activity and exercise test as Cunningham & Faulkner was intense and exhausting. Physical activity questionnaire consisted of 16 questions was used to assess the level of physical activity and Cunningham & Faulkner test was used as intense exercise and exhausting. All blood samples collected from finger capillary in the sitting position. Data were analyzed by SPSS 20 software using independent T, correlated T, covariance analysis and repeated measures variance and Pearson's correlation coefficient tests.
Findings: A significant difference was observed in weight (p=0.031), and BMI (p=0.05), BF (p=0.28) and VF (p=0.01) between active and inactive persons. There was a significant correlation between anthropometric indices and all blood lipid indices (p<0.05), which was inversely correlated regarding HDL-C.
Conclusion: A single-session severe exhausting exercise can increase the LDL-C, TG, TC and LDL-C/HDL-C, while it has no effect on HDL-C level.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Simultaneous Effect of Progesterone Usage and Exercise on Anxiety in Ovariectomized Rats
179
184
FA
Efaf
Karimipour
Biology Department, Science Faculty, Shahid Bahonar University, Kerman, Iran
Mahdi
Abbasnejad
Biology Department, Science Faculty, Shahid Bahonar University, Kerman, Iran
Mahnaz
Kesmati
Biology Department, Science Faculty, Shahid Chamran University, Ahvaz, Iran
Mohammad
Sofiabadi
Physiology Department, Medicine Faculty, Qazvin University of Medical Sciences, Qazvin, Iran
Aims: Sex hormones and exercise may influence anxiety, individually. This study was done to investigate the effect of exercise and progesterone on anxiety in ovariectomized female rats.
Materials & Methods: In this experimental study, 40 adult female Wistar rats weighting 200±20gr were used. They were ovarectomized after anesthesia. They were randomly divided to five groups including control (no treatment), sesame oil, exercise and sesame oil, progesterone (8mg/kg), progesterone and exercise. 30min after intraperitoneally injection of the vehicle or progesterone or before exercise the percentage of animal enterance to the open arms and the percentage of time spent in the open arms were measured.
Findings: Intraperitoneally injection of progesterone (8mg/kg) reduced the mean percentage of open arms entries and the average percentage of time spent in the open arms compared to control group (p<0.05). Doing exercises before injection of progesterone inhibited both progesterone-induced anxiety related symptoms.
Conclusion: Administration of pharmacological doses of the progesterone hormone increases anxiety and physical activity can reduce this effect.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Pain Perception of Different Lancing Sites During Self-Monitoring of Blood Glucose A Comparison of Fingertip with Calf Lancing in Type II Diabetic Patients
185
190
FA
Ali
Mohamadpour
Internal Sergical Department, Nursing & Midwifery Faculty, Gonabad University of Medical Sciences, Gonabad, Iran
Mehdy
Basirimoghadam
“Social Health Research & Development Center” and “Nursing Department, Nursing & Midwifery Faculty”, Gonabad University of Medical Sciences, Gonabad, Iran
Monireh
Tabee
Student Research Committee” and “Nursing Department, Nursing & Midwifery Faculty”, Gonabad University
Aims: Blood sugar control methods improvement in diabetic patients has led to its chronic complications reduction recently. The present study aimed to compare the severity of pain and patient satisfaction of blood sampling from the legs and fingers, since continuous lancet to the finger is painful.
Materials & Methods: This analytical comparative study was done on 260 diabetic patients in the internal wards of two hospitals in 2013-14. The subjects were selected by convenience sampling method. To collect data, demographic questionnaire and satisfaction measurement researcher-made questionnaire were used and the satisfaction rate of blood sampling from finger and leg was measured. Data were entered into SPSS 14.5 software and were analyzed by Chi-square, paired T, Spearman correlation and Mann-Whitney tests.
Findings: Patient satisfaction was significantly higher in blood sampling from the leg than the finger (p<0.001 χ2=18.61). The pain perception of sampling from the leg (7.46±1.31) was significantly lower than sampling from the finger (8.15±0.83) (p<0.001 t=8.16).
Conclusion: The leg causes less pain perception and more patient satisfaction in type II diabetes patients as one of the sites of the blood glucose self-monitoring.
Gonabad University of Medical Sciences
Internal Medicine Today
2981-0086
20
3
2014
9
1
Role of p53 in Apoptosis and Cancer Therapy
191
201
FA
mohammadreza
nooridaluiie
Medical Genetics Department, Medicine Faculty, Tehran University of Medical sciences, Tehran, Iran
Rasoul
Abdollah Zadeh1
Medical Genetics Department, Medicine Faculty, Tehran University of Medical sciences, Tehran, Iran
Introduction: P53 is the most famous tumor suppressor gene that is mutated in over 50% of human cancers. This gene has been described as "guardian of the genome"," the guardian angel gene", and the " master watchman", referring to its critical role in genomic stability, and tumor suppression mainly by inducing apoptosis, cell cycle arrest, and senescence, inhibition of angiogenesis. In this review article were discussed recent advances in p53 research, mainly its role in apoptosis and the approaches to target p53 and its regulators for cancer treatment aimed to either to activate p53 in cancer cells to kill them or temporarily inactivation of p53 in the normal cells to protect them against chemo-radiation.
Conclusion: Due to the vital roles of P53 in carcinogenesis inhibition, this protein is one of the most important therapeutic targets for cancer therapy. Based on genetic variation type in P53, in the normal and tumor cells, a combination of different therapies can be used and also by more comprehensive consideration of the involved signaling pathways new upstream and downstream novel proteins can be discovered to act as targets for new therapeutic targets.