TY - JOUR T1 - The effect of Aerobic exercise training on endothelin-1 concentration in old women TT - تمرین هوازی منظم بر میزان اندوتلین-1 عروق زنان مسن تاثیر JF - QHMS JO - QHMS VL - 17 IS - 4 UR - http://imtj.gmu.ac.ir/article-1-889-en.html Y1 - 2012 SP - 70 EP - 77 KW - :regular exercise KW - vascular endothelium KW - endothelial function N2 - Abstract Background and Aim: Endothelial function deteriorates with aging. On the other hand, exercise training improves the function of vascular endothelial cells. Endothelin-1 (ET-1), which is produced by vascular endothelial cells, is a potent constrictor and therefore, has been implicated in regulation of vascular tonus and progression of atherosclerosis. hypothesized that plasma ET-1 concentration increases with age, even in healthy adults, and that lifestyle modification (i.e., exercise) can reduce plasma ET-1 concentration in previously sedentary old adults. Materials and Methods: measured plasma ET-1 concentration in healthy young (21–28 yr old), healthy middle-aged (31–47 yr old), and healthy old (61–69 yr old) women. The plasma level of ET-1 increased significantly with aging (1.02 ± 0.08, 1.33 ± 0.11, and 2.90 ± 0.20 pg/ml in young, middle-aged, and old women, respectively). Thus plasma ET-1 concentration was markedly higher in healthy old women than in healthy young or middle-aged women (by 3- and 2-fold, respectively). In healthy old women, we also measured plasma ET-1 concentration after 3 month of aerobic exercise (cycling on a leg ergometer at 80% of HRR for 30 min, 5 days/wk). Results: Regular exercise significantly decreased plasma ET-1 concentration in the healthy old women (2.22 ± 0.16 pg/ml, P < 0.01) and also significantly reduced their blood pressure. Conclusion :The present study suggests that regular aerobic-endurance exercise reduces plasma ET-1 concentration in old humans, and this reduction in plasma ET-1 concentration may have beneficial effects on the cardiovascular system . M3 ER -