RT - Journal Article T1 - Effect of Hydroalcholic Extract of Carum Copticum Seed on the Treatment of Peptic Ulcer Induced by Ibuprofen in Rats JF - QHMS YR - 2012 JO - QHMS VO - 18 IS - 1 UR - http://imtj.gmu.ac.ir/article-1-779-en.html SP - 12 EP - 16 K1 - Carum Copticum seed extract K1 - ibuprofen K1 - peptic ulcer K1 - rat AB - Abstract Background and Aim: Non-steroidal anti-inflammatory drugs have been used widely in recent times and generation of peptic ulcer is a side-effect of these drugs. In this study, we evaluated the effect of extract of Carum Copticum seed on treatment of peptic ulcer induced by ibuprofen in rats. Materials and Methods: This study was performed on 30 adult female rats. At first, the animals were randomly divided into five groups. Then, in order to induce gastric ulcer, Ibuprofen was used orally. After suffering, the animals were treated with Omeprazole or plant seed aqueous extract doses of 125, 250 and 500 mg per kg, twice a day for two weeks. Finally, the animals were studied in terms of the number and the extent of gastric ulcer. The amount of liver enzymes, Aspartate Transferase (AST) and Alkaline Transferase (ALT), in the serum of animals were also measured. Results: The plant seed extract caused a dose-dependent ulcer healing effect in rats, that is, the therapeutic effect in doses of 125 and 250 mg/kg compared with Omeprazole was significantly meaningful (p LA eng UL http://imtj.gmu.ac.ir/article-1-779-en.html M3 ER -