TY - JOUR JF - QHMS JO - Intern Med Today VL - 22 IS - 2 PY - 2016 Y1 - 2016/4/01 TI - 8 Weeks of Resistance Training Effect on Myostatin Gene Expression of Myocardium in Healthy Male Wistar Rats TT - اثر 8 هفته تمرین مقاومتی بر بیان ژن میوستاتین عضله قلبی در موش‌های نر ویستار سالم N2 - Aims: Based on the clinical studies, there are higher myostatin gene expression and serum level in cardiovascular patients than the healthy persons. In addition, based on some studies, regular resistance exercises is in line with a reduction in the myostatin gene expression. The aim of this study was to investigate the effects of 8-week resistance exercises on the myostatin gene expressions of myocardium in the healthy male Wistar rats. Materials & Methods: In the experimental study, 13 male adult Wistar rats, aged 15 weeks, were divided into experimental (n=7) and control (n=6) groups. In experimental group, 8-week exercises were done as climbing up a 26-step 1-meter ladder, inclined 85°, with a sinker. (There were 3 sessions a week exercises; each session consisted of 3 sets of 5 repetitions.) 24 hours after the last exercise session and after 12-hour fasting, the rats being dissected, muscle tissue samples were prepared to assess mRNA levels. Data was analyzed in SPSS 16 software using independent T test. Findings: After 8-week resistance exercises, there was no significant difference in the myostatin mRNA expression level in the myocardium between experimental (1.56±0.44) and control (1.94±0.55) groups (p=0.197). Conclusion: 8-week resistance exercises leads to no significant change in the myostatin gene expression of myocardium in the healthy Wistar male rats. SP - 111 EP - 116 AU - Rashidlamir, Amir AU - Basami, Mohammad Reza AU - Attarzadeh Hosseini, Seyyed Reza AU - Hejazi, keyvan AU - Motevalli Anberani, Seyyed Mohamad AD - Sport Physiology Department, Sport Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran KW - Myostatin KW - Gene Expression KW - Resistance Training KW - Myocardium UR - http://imtj.gmu.ac.ir/article-1-2203-en.html DO - 10.18869/acadpub.hms.22.2.111 ER -