TY - JOUR T1 - Evaluation of hydro- alcoholic extract of Plantago majo leaf on the changes in testis Morphology , sperm parameters and testosterone level in Streptozotocin-Induced Diabetic Rats. TT - بررسی اثر عصاره هیدروالکلی برگ بارهنگ درمورفولوژی بافت بیضه و پارامترهای اسپرمی و میزان سطح تستوسترون در موش های نر دیابتی شده با استرپتوزوتوسین JF - QHMS JO - QHMS VL - 20 IS - 1 UR - http://imtj.gmu.ac.ir/article-1-1787-en.html Y1 - 2014 SP - 49 EP - 55 KW - Diabetes KW - Plantain KW - Sperm KW - Leydig Cells KW - Rat N2 - Aims: Diabetes can cause sexual dysfunction in people. The aim of this study was to investigate the effect of leaf extract of plantain (Plantago major) on testis morphology, sperm parameters and serum testosterone levels in the diabetic rats. Methods: 24 male rats were randomly divided into three control (C received normal saline), diabetic (DP) that received 100mg/kg of body weight of extract daily for 42 days intraperitoneally and the diabetic control (D) groups. After treatment, blood samples were collected to determine serum testosterone immediately. Sperms were collected from the epididym tail and sperm count and morphology were evaluated. Tissue sections were prepared from testis and Hematoxylin-Eosin and Oil-Red-Oil staining were done and the slides were examined by light microscope. Data was analyzed by ANOVA test. Results: Treatment with plantain leaf extract significantly increased serum testosterone level significantly in DP group compared to group D (p M3 ER -