AU - kalantari, heibatullah AU - motaharitabar, eisa AU - goudarzi, MEHDI AU - rashidi nooshabadi, mohammadreza TI - The protective effect of hidroalchoholic extract Teucrium polium L against bromobenzene -induced hepatotoxicity in mice PT - JOURNAL ARTICLE TA - QHMS JN - QHMS VO - 19 VI - 4 IP - 4 4099 - http://imtj.gmu.ac.ir/article-1-1749-en.html 4100 - http://imtj.gmu.ac.ir/article-1-1749-en.pdf SO - QHMS 4 AB  - Aims: Teucrium polium is used in Iranian traditional medicine for different diseases. In the present study, protective effect of Teucrium polium L. extract was investigated on bromobenzene-induced hepatotoxicity in mice. Methods: This experimental study was performed on 48 male albino mice. The animals were randomly divided into six groups. Groups 1 and 2 received normal saline and extract of Teucrium polium (500 mg/kg) orally for 10 days, respectively group 3 received bromobenzene (0.36 ml/kg, ip) only on the 10th day groups 4-6 received ethanolic extract orally in doses of 125, 250 and 500 mg/kg, respectively, during 10 days and bromobenzene (0.36 ml/kg, ip) on the 10th day 1 hour after the last dose of extract. Blood and liver samples were collected 24 hours after bromobenzene injection. Then, serum activity of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and directed and total bilirubin were measured. Finally, the biochemical findings were matched with histopathological verifications, the significance of the differences between groups was compared with one-way analysis of variance (ANOVA) followed by Tukey’s posttesting with P-values CP - IRAN IN - LG - eng PB - QHMS PG - 236 PT - Applicable YR - 2014