AU - Sadoughi S.D., TI - Effect of aqueous extract of Ferula assa-foetida’s resin on wound healing of streptozotocin induced diabetic rats PT - JOURNAL ARTICLE TA - QHMS JN - QHMS VO - 19 VI - 3 IP - 3 4099 - http://imtj.gmu.ac.ir/article-1-1745-en.html 4100 - http://imtj.gmu.ac.ir/article-1-1745-en.pdf SO - QHMS 3 AB  - Aims: The aqueous extract of Ferula assa-foetida’s resin has anti-bacterial, anti-inflammatory, anti-oxidant and anti-diabetic effects. The present study was done to evaluate the effect of aqueous extract Ferula assa-foetida’s resin on wound healing in diabetic rats. Methods: In this experimental study, 18 Wistar rats were divided into the normal control (1), diabetic control (2) and diabetics treated with aqueous extract of Ferula assa-foetida’s resin groups. In all groups, 4 wounds (4mm) was created in two lateral posterial parts of body. For 2 days, 3 times a day, the experimental group was topical treatment by extract and control group was treated by normal saline. Inflammatory cells, re-epithelization and vascularization were evaluated on the 4th, 8th and 10th day. Results: Average thickness of the epithelium on the fourth and eighth days in group 3 compared with groups 1 and 2 and on the tenth day in group 2 compared with 1 and 3 significantly increased. Density of inflammatory cells on the fourth day in groups 1 and 3 compared with group 2 and on the eighth and tenth days in group 2 compared with groups 1 and 3 significantly increased. Density of blood vessels on the fourth day in groups 1 and 3 compared with group 2 and on the eighth and tenth days in group 2 compared with groups 1 and 3 significantly increased. Conclusion: Aqueous extract of Ferula assa-foetida’s resin has a great influence on the healing of diabetic ulcers by increasing epithelial cell proliferation and blood vessel formation and accelerate the inflammatory process. CP - IRAN IN - LG - eng PB - QHMS PG - 129 PT - Original YR - 2013