RT - Journal Article T1 - Effect of Ziziphora clinopodioides L. Aqueous Extract on Peptic Ulcer Induced by Acetic Acid in Rats JF - QHMS YR - 2013 JO - QHMS VO - 19 IS - 3 UR - http://imtj.gmu.ac.ir/article-1-1743-en.html SP - 173 EP - 177 K1 - Peptic Ulcer; Ziziphora clinopodioides; Acetic Acid; Rats AB - Aims: For centuries, herbs have been used to avoid disease s . Peptic ulcer is a disease of any part of the stomach or intestines that exposed to acid and activated pepsin . The objective of the present research was to study the effect of Ziziphora clinopodioides aqueous extract on peptic ulcer due to acetic acid in rats. Methods: In this experimental study, 60 Wistar rats weighing approximately 200-250g were randomly divided into 4 groups negative control , positive control, experiment 1 and experiment 2. Initially, rats were operated to give peptic ulcers by acetic acid . A day after stomach ulcer , the experimental groups received Ziziphora clinopodioides aqueous extract for 14 consecutive days and positive control received normal saline . Negative control animals received no substance . Wound healing and fibroblasts , neutrophils and macrophages per unit area were calculated after 14 days . Data was collected using the SPSS 17 software and were analyzed by one-way ANOVA and LSD tests. Results: Wound healing in the experimental group compared to the negative control and positive control groups was significantly increased (p LA eng UL http://imtj.gmu.ac.ir/article-1-1743-en.html M3 ER -