TY - JOUR JF - QHMS JO - Intern Med Today VL - 21 IS - 3 PY - 2015 Y1 - 2015/9/01 TI - Effect of Hydroalcoholic Extract of Kelussia odoratissima Mozaffarian on Uterus Contractions of Mature Rats TT - اثر عصاره الکلی کرفس کوهی بر انقباضات رحم موش صحرایی بالغ N2 - Aims: Kelussia odoratissima is a plant from Umbelliferae family that has nutritional and pharmacological properties. The antispasmodic effect of this plant has been mentioned in Iranian traditional medicine. The aim of study was to assess the effect of alcoholic extract of Kelussia odoratissima on uterus contractions of adult rats. Materials & Methods: In this experimental study, 16 adult female Wistar rats were studied and were randomly divided into two groups (each consisted of 8 rats) receiver of Tyrod solution (first group) and receiver of Dejalon solution (second group) groups. A 10-15mm sample of uterus smooth muscle were placed in an organ bath containing Tyrod or Dejalon solution (10ml), and contractions were recorded with Isometric method after inducing with KCl and Oxytocin. The 0.125, 0.25 and 0.5mg/ml final concentrations of the alcoholic extract of Kelussia odoratissima was added to the organ bath. Data were statistically analyzed by SPSS 17 software using repeated measures ANOVA. Findings: The alcoholic extract of Kelussia odoratissima significantly decreased the KCl-induced (p<0.001) and Oxytocin-induced (p<0.002) contractions in a concentration dependent manner. Conclusion: The alcoholic extract of Kelussia odoratissima inhibits the contractions of adult rat uterus in a concentration dependent manner. Keywords Kelussia odoratissima [Not in MeSH] Uterine Contraction [http://www.ncbi.nlm.nih.gov/mesh/68014590] Rats [http://www.ncbi.nlm.nih.gov/mesh/68051381] Potassium Chloride [http://www.ncbi.nlm.nih.gov/mesh/68011189] Oxytocin [http://www.ncbi.nlm.nih.gov/mesh/68010121] SP - 169 EP - 174 AU - jafarzadeh, lobat AU - Habibian, Roya AU - Rafieian Kopaei, Mahmood AU - Mohammadzade, Zohre AD - Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran KW - Kelussia odoratissima] KW - Uterine Contraction [http://www.ncbi.nlm.nih.gov/mesh/68014590] KW - Rats [http://www.ncbi.nlm.nih.gov/mesh/68051381] KW - Potassium Chloride [http://www.ncbi.nlm.nih.gov/mesh/68011189]Oxytocin [http://www.ncbi.nlm.nih.gov/mesh/68010121] UR - http://imtj.gmu.ac.ir/article-1-2198-en.html DO - 10.18869/acadpub.hms.21.3.169 ER -