TY - JOUR T1 - The relationship between serum levels of hepatic transaminase with histopathological features in patients with chronic Hepatitis B TT - ارتباط سطح سرمی ترانس آمینازهای کبدی با نمای هیستوپاتولوژی در بیماران مبتلا به هپاتیت Bمزمن JF - QHMS JO - QHMS VL - 12 IS - 3 UR - http://imtj.gmu.ac.ir/article-1-58-en.html Y1 - 2006 SP - 17 EP - 22 KW - Hepatic enzyme; Knodell HAI score; Liver biopsy; Chronic hepatitis B N2 - Title: The relationship between serum levels of hepatic transaminase with histopathological features in patients with chronic Hepatitis B Authors: Sh. Semnani , S. Besharat , A. Jabbari , R. Azarhoosh , AA. Keshtkar , MR. Rabiei , Z. Rahmani3, N. Abdollahi , Gh. Roshandel3 Abstract Background and Aim: Continuous evaluation of serum levels of hepatic transaminases' like AST and ALT can show the severity of cellular damage in chronic hepatitis B, also it can be helpful in follow up of hepatic disease progression. This study was designed to detect the relationship and correlation between serum level of enzymes with damage ranking in liver biopsy and inflammation in hepatic cells. Materials and Methods: In this analytic-descriptive study, all blocks of liver biopsy of patients with chronic hepatitis B, taken from 2000 to the first three months of 2004 (for 5 years) in the university hospital, had been overviewed. At first, all liver samples were ranked according to histopathological features, and then were classified according to the severity of inflammation in Knodell HAI score. Based on the patients' files, AST, ALT serum level, sonography report and B hepatitis serological markers like HBeAg, HBeAb and personal identity were registered. Initially, we reviewed clinical findings and analyzed data with statistical tests. Statistical analyses were performed and P value less than 0.05 was significant. Results: We reviewed 86 hepatic biopsies. Mean severity of hepatic inflammation base on Knodell HAI score was 5.133.31.Mean AST, ALT serum level were 86.7444.93 and 105.4450.39, respectively. Serological markers for B hepatitis, HBeAb were reported positive in 53 persons (61.6%). Meanwhile 39 persons (43.3%) were positive for HBeAg. There was noticeable relationship between grading according to Knodell HAI score and qualitative ranking. There was a significant relationship between AST, ALT serum levels and Knodell HAI quantitative score, too (P M3 ER -