TY - JOUR T1 - The assessment of Hypogonadism Occurence and Related Factors among Beta Thalassemia Major Patients using Survival Analysis model TT - بررسی عوامل مرتبط با رخداد هیپوگنادیسم در بیماری تالاسمی ماژور با استفاده از مدل تحلیل بقاء JF - QHMS JO - QHMS VL - 14 IS - 1 UR - http://imtj.gmu.ac.ir/article-1-340-en.html Y1 - 2008 SP - 5 EP - 12 KW - Major thalassemia; Complication; Hypogonadism; Transfusion; Chelation therapy; Survival analysis N2 - Background and Aim: Hypogonadism is the most common endocrinologic complication among major beta thalassemia patients. Absence or irregular chelation therapy in these patients leads to various complications such as hypogonadism. This complication in addition to organic dysfunction, results in behavioral and psychological effects on the patients and their families. The purpose of this study was to evaluate the prevalence and determination of effective factors on occurrence and cumulative risk of this complication. Materials and Methods: 641one thalassemic (316 males and 325 females) patients referring to Cooley’s ward of Dastgheib hospital in Shiraz were studied using a structured questionnaire through enumeration method in 2005-2006. The age of occurrence, demographic information, the age of onset and type of transfusion, and the age of onset and method of chelation therapy were specified. Specialist physicians diagnosed the complication. The data were analyzed using descriptive and analytical (OR confidence interval, chi square test, student T- test and Log Rank test) statistics. Results: Mean ± SD of age in these patients were 17.32 ± 5.3 years. The prevalence of hypogonadism was 18.3%. This complication was seen in 24.9% of girls and 11.4% of boys. Risk of this complication in girls was 2.6 times more than boys (P M3 ER -