Volume 17, Issue 4 (2-2012)                   Horizon Med Sci 2012, 17(4): 70-77 | Back to browse issues page

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1- Islamic azad university branch of shirvan , vahdat.boghrabadi@gmail.com
2- Islamic azad university branch of mashhad
3- Islamic azad university branch of central tehran
4- Islamic azad university branch of shirvan
Abstract:   (8125 Views)
Abstract Background and Aim: Endothelial function deteriorates with aging. On the other hand, exercise training improves the function of vascular endothelial cells. Endothelin-1 (ET-1), which is produced by vascular endothelial cells, is a potent constrictor and therefore, has been implicated in regulation of vascular tonus and progression of atherosclerosis. hypothesized that plasma ET-1 concentration increases with age, even in healthy adults, and that lifestyle modification (i.e., exercise) can reduce plasma ET-1 concentration in previously sedentary old adults. Materials and Methods: measured plasma ET-1 concentration in healthy young (21–28 yr old), healthy middle-aged (31–47 yr old), and healthy old (61–69 yr old) women. The plasma level of ET-1 increased significantly with aging (1.02 ± 0.08, 1.33 ± 0.11, and 2.90 ± 0.20 pg/ml in young, middle-aged, and old women, respectively). Thus plasma ET-1 concentration was markedly higher in healthy old women than in healthy young or middle-aged women (by 3- and 2-fold, respectively). In healthy old women, we also measured plasma ET-1 concentration after 3 month of aerobic exercise (cycling on a leg ergometer at 80% of HRR for 30 min, 5 days/wk). Results: Regular exercise significantly decreased plasma ET-1 concentration in the healthy old women (2.22 ± 0.16 pg/ml, P < 0.01) and also significantly reduced their blood pressure. Conclusion :The present study suggests that regular aerobic-endurance exercise reduces plasma ET-1 concentration in old humans, and this reduction in plasma ET-1 concentration may have beneficial effects on the cardiovascular system .
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Type of Study: Original | Subject: Internal Medicine
Received: 2010/10/8 | Accepted: 2012/02/4 | Published: 2012/02/15