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:: Volume 14, Issue 1 (vol-1 2008) ::
Horizon Med Sci 2008, 14(1): 18-26 Back to browse issues page
The effect of cadmium on tolerance induction to analgesic effects of morphine in rats
MA. Sherafat 1, A. Zarebkohan 2, J. Ghorbi 1, S. Mozafari 1, M. Javan Dr. *3
1- Msc. Student of Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
2- Department of Basic Sciences, Gonabad University of Medical Sciences and Health Services, Gonabad, Iran.
3- Assistant Professor, Department of Physiology, Tarbiat Modarres University, Tehran, Iran. , mjavan@modares.ac.ir
Abstract:   (9134 Views)
Background and Aim: Cadmium element is found in all of tobacco products such as cigarette. There is some evidence that indicate cadmium may interfere with morphine tolerance development. The effect of cadmium on morphine tolerance development and its possible cross tolerance were investigated in this study. Materials and Methods: To induce tolerance to analgesic effect of morphine or cadmium, morphine (15 µg/rat) or cadmium (20 nmol/rat) were injected intrathecally to male rats twice a day for five days. To investigate the effect of cadmium on morphine tolerance, another group of rats were injected intrathecally with cadmium and morphine. Cadmium was applied 15 minutes prior to morphine administration. The analgesic effect of different treatments was measured using tail flick test. Results: The results indicated a long lasting analgesic effect of cadmium which was obvious after 12 hours. Repetitive administration of cadmium caused tolerance development to its analgesic effect. In animals which received cadmium during first 5 days, morphine could not induce a significant analgesia on day 6 (cross tolerance). The comparison of the tail flick latencies in morphine and cadmium+morphine treated groups, did not show a significant difference, indicated that cadmium did not have any inhibitory effect on development of morphine tolerance. Conclusion: Our results showed that intrathecal administration of cadmium causes cross-tolerance to analgesic effect of morphine. It seems that, cadmium of cigarettes which induces analgesia by itself causes morphine tolerance and develops some aspect of morphine addiction.
Keywords: Morphine; Tolerance; Cadmium; Lumbar spinal cord; Rat
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Type of Study: Original | Subject: Internal Medicine
Received: 2008/11/10
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Sherafat M, Zarebkohan A, Ghorbi J, Mozafari S, Javan M. The effect of cadmium on tolerance induction to analgesic effects of morphine in rats. Horizon Med Sci . 2008; 14 (1) :18-26
URL: http://hms.gmu.ac.ir/article-1-342-en.html
Volume 14, Issue 1 (vol-1 2008) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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