Volume 26, Issue 2 (Spring 2020)                   Horizon Med Sci 2020, 26(2): 142-155 | Back to browse issues page


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Aboeepoor S, Dehghani Ashkezari M, Aboee-Mehrizi F, Haghiralsadat B F, Nikoonahad Lotfabadi N. Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer. Horizon Med Sci. 2020; 26 (2) :142-155
URL: http://hms.gmu.ac.ir/article-1-3312-en.html
1- Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran., Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
2- Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran. , aboeef@yahoo.com
3- Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Department of Biology, Faculty of Basic Sciences, Science and Arts University, Yazd, Iran., Department of Biology, Faculty of Basic Sciences, Science and Arts University, Yazd, Iran.
Abstract:   (675 Views)
Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug delivery systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used in this study to prepare the optimized formulation of niosomes containing extract, and to evaluate its cytotoxicity.
Methods & Materials Initially, the extract of Iranian Nepta (N. persica) was prepared. Then, the nano-niosomal system, containing the extract was designed and synthesized using cholesterol and Span-60. The physicochemical properties of the system were evaluated by FTIR and SEM. MTT assay [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was used to determine the toxicity of the Nepta extract and nano-system containing it against bone cancer cells (MG63).
Findings An optimized formulation was obtained using cholesterol and Span-60 with a ratio of 80:20. The amount of extract release from this formulation continued with a steady slope over a long period of time. The survival rate of MG63 cells against 100 μg/mL of the free form of N. persica extract and its niosomal form were 22% and 8.88%, respectively.
Conclusion The present research results suggested that N. persica extract exert anti-cancer effects and niosome could improve its anti-cancer efficiency. Therefore, it could be used as a proper carrier to deliver the extract to the target tissue.
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Type of Study: Original | Subject: Basic Medical Science
Received: 2019/06/8 | Accepted: 2019/11/13 | Published: 2020/06/21
* Corresponding Author Address: Faculty of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

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