Volume 24, Issue 4 (FALL 2018)                   Horizon Med Sci 2018, 24(4): 263-269 | Back to browse issues page

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Hamidi G, Salami M, Talaei A. Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats. Horizon Med Sci. 2018; 24 (4) :263-269
URL: http://hms.gmu.ac.ir/article-1-2992-en.html
1- Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
2- Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran. , talaei@kaums.ac.ir
Abstract:   (1396 Views)

Aims: Facing maternal separation during early postnatal life leads to disturbances in the cognitive and neuro-chemical activities of the brain. The aim of this study was to investigate the effects of maternal separation on spatial learning and memory of morphine-dependent rats.

Materials and Methods: This experimental study was carried out on 40 male Wistar rats of 45 days old. Animals were divided into control group (CO), morphine dependent (MD) and 3 group of rats which maternally separated during 1 (MS1), 2 (MS2) and 3 weeks (MS3) after birth. Except CO rats, the other groups were subcutaneously injected 10 mg/kg morphine every 12 hours for 10 days. At the 11th day signs of withdrawal syndrome were evaluated and during next 4 consecutive days spatial learning was evaluated by Morris water maze (MWM). The rats’ spatial memory retrieval was also estimated at the last day.

Findings: Although morphine dependence did not affects spatial learning and memory of rats, but 3 weeks maternal separation caused the animals spend more time and travel more distance to find the hidden platform than to CO group (P<0.001 for both of comparisons). Also, they spent less time and passed less distance in the target quadrant in probe trial (P<0.001 for both of comparisons).

Conclusion: In conclusion, maternal separation impairs spatial learning and memory of rats.

Full-Text [PDF 487 kb]   (329 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2018/02/24 | Accepted: 2018/08/6 | Published: 2018/09/22

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