Aims: Imbalance and disruption in daily functioning (sitting, standing up and walking) are major clinical symptoms of MS, while physical activity and exercise is an important non-pharmacological method in the rehabilitation and control of clinical signs of the disease.

Materials & Methods: Combined exercise + Q10 and combined exercise groups performed a combined exercise program including two sessions of aerobic training (50 to 60 max HR at the beginning to the end) and one session of resistance training (50-60% 1RM from beginning to end) three sessions per week. Daily 200 mg of CoQ10 supplement was prescription in capsule form and starch was also used as placebo. Endurance and speed of walk were measured by using of up & go, 25 foot walking, 6 min walking and chair stand test before and after training protocol. Data were analyzed with analysis of covariance and t-test at a significance level of P<0.05.

Findings: The results showed a significant decrease in the time of the standing and sitting tests, also a significant increase in endurance and speed of walking in combined exercise training + Q10 supplementation and combined exercise training groups versus Q10 supplementation and placebo groups.

Conclusion: Combined exercise training with coenzyme Q10 supplementation or alone can lead to improved muscular function such as sitting, standing and walking in patient with MS. Therefore, this method can be used as a complementary tool in addition to drug therapy for the improvement of clinical symptoms of these patients.