Volume 21, Issue 2 (Summer 2015)                   Horizon Med Sci 2015, 21(2): 129-134 | Back to browse issues page


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Mansouri A, Zayeri F, Baghestani A R, Ghorbanifar Z, Delavar Kasmaei H, Sheidaei A. Effect of Coriander Fruit on Clinical Course of Migraine Patients: A Comparison between Random Effect and Transition Models. Horizon Med Sci. 2015; 21 (2) :129-134
URL: http://hms.gmu.ac.ir/article-1-2170-en.html
1- Biostatistics Department, Paramedical Sciences Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- “Proteomics Research Center” and “Department of Biostatistics, Faculty of Paramedical Sciences”, Shahid Beheshti University of Medical Sciences, Tehran, Iran , fzayeri@gmail.com
3- Traditional Medicine Department, Traditional Medicine School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Neurology Department, Medicine Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (3361 Views)

Aims: Among all types of headache, migraine is the third most prevalent disorder and seventh common cause of disability. In Old Persian medical literature, Coriander fruit have been introduced as a treatment of headache. The aim of this study was exploring the effect of Coriander fruit on severity and duration of migraine attacks. Materials & Methods: This randomized triple-blind, placebo-controlled clinical trial was conducted in the neurology clinic of Shohadaye Tajrish hospital in Tehran. Based on sample size formula for longitudinal data, a total number of 66 patients were randomly assigned into intervention and control groups. Intervention group received common medicine plus Coriander fruit and the control group received common medicine plus placebo and both were followed during four weeks after intervention. For analyzing the data, random effect and transition models were utilized and the results were compared using Akaike criteria. Findings: The average of attacks duration in the intervention group was 4.27 hours less than the control group (p<0.001). Also, mean severity of migraine attacks in the intervention group was 2.81 (based on VAS scale) less than control group (p<0.001). Conclusion: Coriander fruit reduces the duration and severity of migraine attacks. Also, considering the duration and severity of last migraine attacks is necessary for prediction.

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Type of Study: Original | Subject: Basic Medical Science
Received: 2015/03/5 | Accepted: 2015/05/10 | Published: 2015/05/24

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