Volume 19, Issue 3 (Fall 2013)                   Horizon Med Sci 2013, 19(3): 129-135 | Back to browse issues page

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Sadoughi S.D.. Effect of aqueous extract of Ferula assa-foetida’s resin on wound healing of streptozotocin induced diabetic rats. Horizon Med Sci. 2013; 19 (3) :129-135
URL: http://hms.gmu.ac.ir/article-1-1745-en.html
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran , damoon.sadughi@gmail.com
Abstract:   (3956 Views)

Aims: The aqueous extract of Ferula assa-foetida’s resin has anti-bacterial, anti-inflammatory, anti-oxidant and anti-diabetic effects. The present study was done to evaluate the effect of aqueous extract Ferula assa-foetida’s resin on wound healing in diabetic rats.

Methods: In this experimental study, 18 Wistar rats were divided into the normal control (1), diabetic control (2) and diabetics treated with aqueous extract of Ferula assa-foetida’s resin groups. In all groups, 4 wounds (4mm) was created in two lateral posterial parts of body. For 2 days, 3 times a day, the experimental group was topical treatment by extract and control group was treated by normal saline. Inflammatory cells, re-epithelization and vascularization were evaluated on the 4th, 8th and 10th day.

Results: Average thickness of the epithelium on the fourth and eighth days in group 3 compared with groups 1 and 2 and on the tenth day in group 2 compared with 1 and 3 significantly increased. Density of inflammatory cells on the fourth day in groups 1 and 3 compared with group 2 and on the eighth and tenth days in group 2 compared with groups 1 and 3 significantly increased. Density of blood vessels on the fourth day in groups 1 and 3 compared with group 2 and on the eighth and tenth days in group 2 compared with groups 1 and 3 significantly increased.

Conclusion: Aqueous extract of Ferula assa-foetida’s resin has a great influence on the healing of diabetic ulcers by increasing epithelial cell proliferation and blood vessel formation and accelerate the inflammatory process.

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Type of Study: Original | Subject: Basic Medical Science
Received: 2013/04/13 | Accepted: 2013/10/8 | Published: 2013/10/8

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