Volume 19, Issue 3 (Fall 2013)                   Horizon Med Sci 2013, 19(3): 173-177 | Back to browse issues page

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Mousavi Mobarake Sh., Rahnama M., Bigdeli M.R., Nasiri Semnani Sh.. Effect of Ziziphora clinopodioides L. Aqueous Extract on Peptic Ulcer Induced by Acetic Acid in Rats. Horizon Med Sci. 2013; 19 (3) :173-177
URL: http://hms.gmu.ac.ir/article-1-1743-en.html
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Abstract:   (4638 Views)

Aims: For centuries, herbs have been used to avoid disease s . Peptic ulcer is a disease of any part of the stomach or intestines that exposed to acid and activated pepsin . The objective of the present research was to study the effect of Ziziphora clinopodioides aqueous extract on peptic ulcer due to acetic acid in rats.

Methods: In this experimental study, 60 Wistar rats weighing approximately 200-250g were randomly divided into 4 groups negative control , positive control, experiment 1 and experiment 2. Initially, rats were operated to give peptic ulcers by acetic acid . A day after stomach ulcer , the experimental groups received Ziziphora clinopodioides aqueous extract for 14 consecutive days and positive control received normal saline . Negative control animals received no substance . Wound healing and fibroblasts , neutrophils and macrophages per unit area were calculated after 14 days . Data was collected using the SPSS 17 software and were analyzed by one-way ANOVA and LSD tests.

Results: Wound healing in the experimental group compared to the negative control and positive control groups was significantly increased (p<0.05) . By passing time, the number of neutrophils and macrophages were increased in experimental groups and the number of fibroblasts was reduced .

Conclusion: Ziziphora clinopodioides extract is effective in the treatment of peptic ulcer induced by acetic acid.

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Type of Study: Applicable | Subject: Physiology
Received: 2013/04/10 | Accepted: 2013/10/21 | Published: 2013/10/21

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