Volume 17, Issue 3 (10-2011)                   Horizon Med Sci 2011, 17(3): 28-34 | Back to browse issues page

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Moheghi N, Afshari J T, Brook A. The Cytotoxic Effect of Zingiber Afficinale in Breast Cancer (MCF7) Cell Line. Horizon Med Sci. 2011; 17 (3) :28-34
URL: http://hms.gmu.ac.ir/article-1-1282-en.html
1- , Mashhad University of Medical Sciences , moheghin1@mums.ac.ir
2- , Mashhad University of Medical Sciences
Abstract:   (10326 Views)


  Background and Aim: Breast cancer is the most common cancer affecting women. It is the second common cancer (after lung cancer) in women. Zingiber afficinale is used as a traditional medicine. Recently, the biological activities of Zingiber afficieale plants have been reported as possessing anticancer, antibacterial, antiulcer, antifungal, and insecticidal properties. However, the antitumor effects of this medicine have not been studied in cancer cell lines. The aim of this study was to investigate the antitumor effect of Zingiber afficieale on breast cancer cell lines.

  Materials and Methods: Breast cancer (MCF7) cell lines and normal connective tissue cell line (L929) were cultured in DMEM medium. Zingiber afficinale was extracted and different dilutions of Zingier extract (1.60 to 1.200) were added to cell culture. Cell viability was quantitated by MTT assay after 24, 48 and 72 hours.

  Results: The effects of Zingiber afficieale on cell viability were observed after 48 hours on cell lines. Ginger doses in dilution 1.100 and 1.70 inhibited 50% cell growth (IC50) in MCF7 cell line after 48 hours of incubation, respectively.

  Conclusion: Our study shows that ginger fresh extract has cytotoxic effects on tumor cells, but it does not have any cytotoxic effect on normal cells. It seems that ginger could be considered as a promising chemotherapeutic agent in cancer treatment.

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Type of Study: Original | Subject: Basic Medical Science
Received: 2011/09/23 | Published: 2011/10/15
* Corresponding Author Address: Immunogenetic and Cell Culture, Immunology Research Center, BuAli Institute, Mashhad University of Medical Sciences, Mashhad, Iran

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