Volume 18, Issue 4 (Winter 2013)                   Horizon Med Sci 2013, 18(4): 161-164 | Back to browse issues page

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Solouki M, Mohammad Taheri Z. Diagnostic sensitivity of pleural cytology by considering fluid volume. Horizon Med Sci. 2013; 18 (4) :161-164
URL: http://hms.gmu.ac.ir/article-1-1177-en.html
1- Department of Internal Medicine, Faculty of Medicine, Shahid-Beheshti University of Medical Sciences, Tehran, Iran , solooki@sbmu.ac.ir
2- Department of Pathology, Faculty of Medicine, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (4351 Views)

Aims: Considering the prevalence of pleural malignancy, its diagnosis is of great importance in terms of treatment and prognosis and management. The present study was conducted to evaluate the cytological value of pleural fluid in the diagnosis of malignancy of two aspects, namely, cytological sensitivity and impact of fluid volume studied in the diagnosis of pleural malignancy.

Methods: This cross sectional descriptive study was done in Masih- Daneshvari hospital in Tehran, Iran, during a period of 24 months and 318 samples were selected and analyzed by linear sampling method. After centrifugation, smears and cell blocks were obtained and evaluated from pleural fluid samples. Decisive pathological findings in terms of the presence of malignant cells were reported to be positive. All patients were followed up for 6 months up to the final diagnosis after pleural fluid cytology diagnosis. Data collected by statistical software SPSS 18 were analyzed with Chi-square test.

Results: 58 cases of cytological results were positive in terms of malignancy. Cytological sensitivity in the diagnosis of malignancy was 41.73% and its negative predictive value was 68.85%. The feature and positive value of the given test were 100%. The highest sensitivity regarding the cytological diagnosis was associated to the sample volume range over 40ml (65%) and next in the volume range of 31-40ml (63.7%).

Conclusion: The pleural fluid volume is of great importance in achieving a diagnosis. In addition, considering the significance of the acceleration in the diagnosis, at least 31-40 ml of fluid should be taken to be tested in each thoracentesis time.

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Type of Study: Applicable | Subject: Diseases
Received: 2011/06/25 | Accepted: 2013/05/5 | Published: 2013/05/5

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