Volume 26, Issue 4 (Autumn 2020)
Intern Med Today 2020, 26(4): 432-447 |
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Pourlak T, Halimi M, Pourlak T, Maroufi P, Ghaderpour S, Shokoohi A. Effect of Extracts of Cloves (Syzygium Aromaticum) on Hepatic Cell Damage and Oxidative Stress Caused by Diabetes in Adult Rats. Intern Med Today 2020; 26 (4) :432-447
URL: http://imtj.gmu.ac.ir/article-1-3534-en.html
URL: http://imtj.gmu.ac.ir/article-1-3534-en.html
Tala Pourlak1 
, Monireh Halimi1 , Tannaz Pourlak2 , Parham Maroufi * 3, Saber Ghaderpour4 , Arefeh Shokoohi5
, Monireh Halimi1 , Tannaz Pourlak2 , Parham Maroufi * 3, Saber Ghaderpour4 , Arefeh Shokoohi5
1- Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2- Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran.
3- Department of Orthopedics, Shohada Medical Research, School of Medicine, Tabriz University of Medical Sciences,Tabriz, Iran. , drparhammarofi@gmail.com
4- Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Student Research Committee, North Khorasan University of Medical Sciences, Bojnord, Iran.
5- Student Research Committee, North Khorasan University of Medical Sciences, Bojnord, Iran.
2- Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran.
3- Department of Orthopedics, Shohada Medical Research, School of Medicine, Tabriz University of Medical Sciences,Tabriz, Iran. , drparhammarofi@gmail.com
4- Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Student Research Committee, North Khorasan University of Medical Sciences, Bojnord, Iran.
5- Student Research Committee, North Khorasan University of Medical Sciences, Bojnord, Iran.
Abstract: (2574 Views)
Aims: In this study, we investigated the effect of clove extract (Syzygium aromaticum) on liver cell damage and oxidative stress caused by diabetes in adult rats.
Methods & Materials: For this study, 28 female rats were collected and divided into four groups: A: Control group; B: Diabetic Control group (DC) which received 20% glycerol dissolved in normal saline as carriers; C: Diabetic rats (DSA) treated with cloves hydroalcoholic extract (4 mg/kg); d) diabetic rats (DG) treated with glibenclamide (5 mg/kg) as a standard drug.
Findings: The fasting blood sugar and serum triglyceride levels in the DC group increased significantly compared to the control group (P<0.05). In DC, DG, and DSA groups, high-density lipoprotein, and serum insulin levels decreased significantly compared to the control group (P<0.05). Also, in DG and DSA groups, high-density lipoprotein and serum insulin levels increased significantly compared to the DC group.
Conclusion: Cloves can affect fasting blood sugar, serum insulin levels, serum fat profile levels, and prevent liver tissue damage in diabetic rats caused by streptozotocin.
Methods & Materials: For this study, 28 female rats were collected and divided into four groups: A: Control group; B: Diabetic Control group (DC) which received 20% glycerol dissolved in normal saline as carriers; C: Diabetic rats (DSA) treated with cloves hydroalcoholic extract (4 mg/kg); d) diabetic rats (DG) treated with glibenclamide (5 mg/kg) as a standard drug.
Findings: The fasting blood sugar and serum triglyceride levels in the DC group increased significantly compared to the control group (P<0.05). In DC, DG, and DSA groups, high-density lipoprotein, and serum insulin levels decreased significantly compared to the control group (P<0.05). Also, in DG and DSA groups, high-density lipoprotein and serum insulin levels increased significantly compared to the DC group.
Conclusion: Cloves can affect fasting blood sugar, serum insulin levels, serum fat profile levels, and prevent liver tissue damage in diabetic rats caused by streptozotocin.
Type of Study: Original |
Subject:
Laboratory Medicine
Received: 2020/05/17 | Accepted: 2020/08/17 | Published: 2020/10/1
Received: 2020/05/17 | Accepted: 2020/08/17 | Published: 2020/10/1
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