Volume 27, Issue 2 (Spring 2021)                   Horizon Med Sci 2021, 27(2): 214-229 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sanjari R, Hosseini S E. Effects of Perinatal and Neonatal Sodium Nitrite on Serum Levels of Uric Acid, Urea, Creatinine, and Tissue Structure of Rats’ Offspring Kidneys. Horizon Med Sci. 2021; 27 (2) :214-229
URL: http://hms.gmu.ac.ir/article-1-3509-en.html
1- Department of Biology, Faculty of Science, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
2- Department of Biology, Faculty of Science, Zand Institute of Higher Education, Shiraz, Iran. , ebrahhim.hossini@yahoo.cm
Abstract:   (353 Views)
Aims: Sodium nitrite is a food preservative that can endanger human health. This study aimed to investigate the perinatal and neonatal effects of sodium nitrite on the functional and tissue structure of rats’ offspring kidneys.
Methods & Materials: In this experimental study, 56 female rats were divided into seven groups (n=8): control, perinatal and neonatal control groups, experimental groups 1 and 2 perinatal and neonatal (under oral treatment of doses of 90 and 180 mg/kg sodium nitrite during pregnancy and lactation). At the end of infancy, 8 offspring of rats were randomly selected from each group. After blood sampling, creatinine, urea, and uric acid levels were measured, and by extracting their kidneys, histopathological evaluation was performed.
Findings: Perinatal and neonatal administration of 90 and 180 mg/kg sodium nitrite impaired renal tissue structure and significantly increased serum levels of creatinine, urea, and uric acid levels (P<0.001) in rats’ offspring compared to those in the control groups.
Conclusion: Sodium nitrite consumption during pregnancy and lactation increases the serum levels of urea, uric acid, and creatinine by changing the tissue structure of the offspring kidneys.
Full-Text [PDF 4708 kb]   (184 Downloads) |   |   Full-Text (HTML)  (161 Views)  
Type of Study: Original | Subject: Basic Medical Science
Received: 2020/03/29 | Accepted: 2020/10/6 | Published: 2021/04/1

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | The Horizon of Medical Sciences

Designed & Developed by : Yektaweb