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:: Volume 25, Issue 1 (Winter 2019) ::
Horizon Med Sci 2019, 25(1): 16-21 Back to browse issues page
The Effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats
M. Paseban 1 , V. Mousavi Fayzabadi 2 , N. Tayyebi Meibodi 3 , M. Yousefi 4 , Azar Hosseini Doctor5 , H. Rakhshandeh 6
1- Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Biochemistry, Faculty of Basic Science, Mashhad University of Payam Noor, Mashhad, Iran
3- Department of Pathology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
6- Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran , RakhshandehH@mums.ac.ir
Abstract:   (34 Views)

Aims: Plantago major is used in traditional medicine for the treatment of gastrointestinal disorders. The purpose of this study was to examine the effect of hydro – alcoholic extract of Plantago major on indomethacin-induced gastric ulcer in rats.
Materials & Methods: 72 male Wistar rats were used in this experimental study. In treatment groups, animals received indomethacin (35 mg/kg) as single dose for induces stomach ulcer, then rats were gavaged by ranitidine (50 mg/kg) and different doses of the extract (200 mg/kg, 400 mg/kg and 800 mg/kg) for 3 days. In preventive groups, animals were treated by ranitidine and different doses of extract for 3 days, and then indomethacin was gavaged on 4th day for stomach ulcer induction. Gastric mucosal damage and acid secretion were evaluated 6 hours later. Statistical analysis was performed using one-way ANOVA.
Findings: Acid secretion significantly decreased in therapeutic group that received 200 mg/kg dose of the extract and in preventive groups that received different doses of the extract (p<0.05). Also macroscopic results showed all doses of extract in preventive groups and 200 mg/kg and 800 mg/kg doses of extract in therapeutic groups significantly decreased ulcer index (p<0.05, p<0.01).
Conclusion: Hydro – alcoholic extract of Plantago major can protect the gastric mucosa against indomethacin-induced gastric ulcer, via decreasing of gastric acid secretion.
 

Keywords: Stomach ulcer: [https://www.ncbi.nlm.nih.gov/mesh/?term=Stomach+ulcer], Indomethacin: [https://www.ncbi.nlm.nih.gov/mesh/68007213], Plantago major: [https://www.ncbi.nlm.nih.gov/mesh/68010943], Gastric acid: [https://www.ncbi.nlm.nih.gov/mesh/6800574
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Type of Study: Original | Subject: Gastroenterology and Hepatology
Received: 2017/05/14 | Accepted: 2018/10/13 | Published: 2018/12/22
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Paseban M, Mousavi Fayzabadi V, Tayyebi Meibodi N, Yousefi M, Hosseini A, Rakhshandeh H. The Effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats. Horizon Med Sci . 2019; 25 (1) :16-21
URL: http://hms.gmu.ac.ir/article-1-2766-en.html


Volume 25, Issue 1 (Winter 2019) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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