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:: Volume 23, Number 3 (Summer 2017) ::
Horizon Med Sci 2017, 23(3): 174-180 Back to browse issues page
Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population
N. Roshani Pour1, M. Jabbarpour Bonyadi *2, M.H. Jabbarpour Bonyadi3
1- Center of excellence for bio diversity Department, Natural Sciences Faculty, University of Tabriz, Tabriz, Iran
2- Post Address: Natural Sciences Faculty, University of Tabriz, 29 Bahman Street, Tabriz, Iran , jabbarpour@tabrizu.ac.ir
3- Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (123 Views)

Aims: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness and debilitating in old stages, in developed and developing countries that engage the central part of the retina or macula. The aim of this study was to evaluate the relationship of the rs4151667 position of the complement factor B gene polymorphism with AMD (dry type with geographic atrophy phenotype) in the North East of Iran population.

­Materials & Methods:­ In this descriptive cross-sectional study in 2015-2016, 44 AMD patients (dry type with geographic atrophy phenotype) were randomly selected from Gonabad City, Iran, health centers as the patient group. 50 healthy individuals from the same society that have no relative relations with each other or the patients, but were adapted by age and sex to the patient group, were selected as the control group. The ­­polymorphism of rs4151667 (c.26T>A)­ position of the complement factor B gene was determined for all samples by Restriction Fragment Length Polymorphism (RFLP). Data was analyzed the Chi-square test in 2x2.Contingency software.

Findings: The frequency of TT genotype in AMD patients (95.5%) was significantly (p=0.048) more than the control group (88.0%), but the frequency of AT genotype in AMD patients (4.5%) was significantly (p=0.025) less than the control group (12.0%).

Conclusion: The polymorphism of rs4151667 (c.26T>A) position of complement factor B is effective on the development of AMD in North East of Iran population.

Keywords: Age-related macular degeneration, Complement Factor B, Polymorphism, Genetic, RFLP
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Type of Study: Original | Subject: Basic Medical Science
Received: 2016/12/15 | Accepted: 2017/03/13 | Published: 2017/06/10
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Roshani Pour N, Jabbarpour Bonyadi M, Jabbarpour Bonyadi M. Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population. Horizon Med Sci . 2017; 23 (3) :174-180
URL: http://hms.gmu.ac.ir/article-1-2657-en.html
Volume 23, Number 3 (Summer 2017) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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