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Background and Aim: Breast feeding is significantly important in mothers and infants health and finan -cially beneficial for the country. This research was done to evaluate the impact of using "shirafza drop" by nursing mothers on weight gain (WG) of 0-6 months exclusively breastfed. Materials and Methods: The study was done by clinical trial of prespectively in two groups included of 158 breast fed mothers referring to health centers having problems in their infants weight gain received Shirafza Drop for 4 weeks (30 drops in 3 separate dose ). This drug was prepared of six increasing milk plants: Foeniculum Volgare, Pimpinella Anisum, Cuminum Cyminum, Nigella Sativa, Anetom Gravolen and Petroselinum Crispum. The control received placebo (solution of chlorophyl in alcohol). The data were gathered by a questionnaire and follow up forms in five stages and infants were weighted in each stage. The data calculation was made by the chi- square test, analysis variance and analysis of co-variance and t-test. Results: The mean of total WG of infants at all stages in the case group (471.1±222.9 g) and the control group (554.7±321.1) weren’t statistically significant. (P=0.5) and there was not any significant relationship in the rate of mothers milk emotionally, the least WG in the first 3month (26 g/daily) and in the second 3 month (17 g/daily ) then, the comparison of the two groups showed that the infants more than 3 months gained the least weight. Conclusion: According to this research data using Shirafza Drop by nursing mothers don’t have any effect on 0-6 month infants’ weight gain

Keywords: Exclusive breastfeeding; Milk deficiency; Prolactine

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