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:: Volume 23, Number 1 (Winter 2017) ::
Horizon Med Sci 2017, 23(1): 27-33 Back to browse issues page
Effect of Curcumin and Low Frequency Electromagnetic Field on the Hormones of Pituitary-Gonad Axis in Male Diabetic Rats
D. Sadoughi *
Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Iran , Damoon.sadughi@gmail.com
Abstract:   (608 Views)

Aims: Changing the activity of pituitary-testis axis, hyperglycemia leads to fertility disorders. Curcumin reduces blood sugar, and the electromagnetic fields differently affect the cells and tissues. The aim of the study was to investigate the effects of curcumin and the low-frequency electromagnetic fields on the activities of pituitary-gonad axis in the diabetic male rats.

Materials & Methods: In the experimental study, 49 Wistar male rats were studied.  The rats were randomly divided into seven groups (n=7 rats per group), including healthy control, diabetic control (receiving distilled water), experimental diabetic 1 (300mg/Kg curcumin as intraperitoneal injection), experimental diabetic 2 (curcumin + 60-minute 50Hz and 15G electromagnetic field daily), experimental diabetic 3 (curcumin + 50Hz and 300G electromagnetic field), experimental diabetic 4 (50Hz and 15G electromagnetic field), and experimental diabetic 5 (50Hz and 300G electromagnetic field) groups. One alloxan intraperitoneal injection was used to cause diabetes. 25-day treatment was conducted in all the groups. At the end of treatment period, the serum levels of testosterone, dihydro-testosterone, estrogen, LH, and FSH hormones were measured. Data was analyzed by SPSS 20 software using one-way ANOVA and Tukey post-hoc tests.

Findings: The serum levels of all the studied hormones significantly increased in experimental diabetic groups 1, 2, and 4 compared to diabetic control group, while they significantly decreased in experimental diabetic group 5 (p<0.05).

Conclusion: Curcumin increases the activity level of pituitary-testis axis in the diabetic male rats. The effects intensify by the simultaneous 15G electromagnetic field.  

Keywords: Diabetes, Curcumin, Electromagnetic Fields, Testis, Pituitary-Gonad Axis, Rats
Full-Text [PDF 559 kb]   (355 Downloads)    
Type of Study: Original | Subject: Basic Medical Science
Received: 2016/01/26 | Accepted: 2016/05/21 | Published: 2016/12/31
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DOI: 10.18869/acadpub.hms.23.1.27


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Sadoughi D. Effect of Curcumin and Low Frequency Electromagnetic Field on the Hormones of Pituitary-Gonad Axis in Male Diabetic Rats. Horizon Med Sci . 2017; 23 (1) :27-33
URL: http://hms.gmu.ac.ir/article-1-2441-en.html
Volume 23, Number 1 (Winter 2017) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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