[Home ] [Archive]   [ فارسی ]  
:: Volume 23, Number 1 (Winter 2017) ::
Horizon Med Sci 2017, 23(1): 63-67 Back to browse issues page
Effect of Sildenafil in Protection of Contralateral Testis Following Unilateral Blunt Testicular Trauma in Mouse
R. Moeini Moghaddam1, A. Shalizar Jalali *2, Gh. Najafi3, M. Behfar3
1- Basic Sciences Department, Veterinary Medicine Faculty, Urmia University, Urmia, Iran
2- Basic Sciences Department, Veterinary Medicine Faculty, Urmia University, Urmia, , a.shalizar@urmia.ac.ir
3- Surgery & Diagnostic Imaging Department, Veterinary Medicine Faculty, Urmia University, Urmia, Iran
Abstract:   (1568 Views)

Aims: Caused mainly by the contact sports, the non-penetrating testicular trauma in some children might produce post-maturity fertility problems in men. The aim of the study was to investigate the adjacent-testis protective role of sildenafil after the non-penetrating one-way testicular trauma in the rats.

Materials & Methods: In the experimental study, 24 non-mature male rats (20 days old) were studied. The rats were randomly divided into four 6-rat groups including control, non-penetrating trauma, non-penetrating trauma + sildenafil, and sildenafil groups. To produce the non-penetrating trauma, the belly being opened, the right testis, put on a sterile constant level, was hit by a sterile 5g weight released from 10cm height. 0.1mg/kg sildenafil were administrated as intra-peritoneal injection daily and for 7 days after the trauma. The left testis of all the rats, removed in their 70 days old, were histologically investigated. Data was analyzed using one-way ANOVA and Tukey’s post-hoc tests. 

Findings: The trauma significantly reduced the mean diameter of the seminiferous tubules, their germinal epithelium height, and the spermatogenesis indices. In addition, such trauma caused different morphological changes in the adjacent testis of the rats. All the parameters were considerably improved by the administration of sildenafil (p<0.05). 

Conclusion: The sildenafil can protect the rats against the fertility disorders caused by the non-penetrating one-way testis trauma. 

Keywords: Wounds, Non-Penetrating, Testis, Sildenafil, Mice
Full-Text [PDF 766 kb]   (365 Downloads)    
Type of Study: Original | Subject: Basic Medical Science
Received: 2015/11/15 | Accepted: 2016/07/19 | Published: 2016/12/31
Send email to the article author



DOI: 10.18869/acadpub.hms.23.1.63


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moeini Moghaddam R, Shalizar Jalali A, Najafi G, Behfar M. Effect of Sildenafil in Protection of Contralateral Testis Following Unilateral Blunt Testicular Trauma in Mouse. Horizon Med Sci . 2017; 23 (1) :63-67
URL: http://hms.gmu.ac.ir/article-1-2354-en.html
Volume 23, Number 1 (Winter 2017) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
Persian site map - English site map - Created in 0.049 seconds with 783 queries by yektaweb 3503