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Horizon Med Sci 2016, 22(3): 229-235 Back to browse issues page
Comparison the Protective Effects of L-Carnitine and Acetyl L-Carnitine on Blood Glucose and Lipid Peroxidation Level in Diabetic Rats
M.R. Hajinezhad 1, Sh. Hajian2, S. Saghayei2, A.R. Samzadeh-Kermani2, R. Nabavi2
1- Basic Science Department, Veterinary Medicine Faculty, University of Zabol, Zabol, Iran , hajinezhad@uoz.ac.ir
2- Basic Science Department, Veterinary Medicine Faculty, University of Zabol, Zabol, Iran
Abstract:   (1104 Views)

Aims: New medications with less side-effect are increasingly noticed now a day. L-Carnitine and Acetyl L-Carnitine reduce the secondary side-effects of Type I diabetes. The aim of this study was to investigate the effects of oral administration of the materials on the blood glucose and the lipid per-oxidation of the liver and brain tissues in the diabetic rats.

Materials & Methods: In the experimental study, 50 male Wistar rats were studied. The rats were randomly divided into five groups including control (the healthy rats), negative control (the diabetic rats), and three treatment diabetic groups. The diabetic groups received 110mg/Kg alloxan via injection to become diabetic. The treatment groups received L-Carnitine, Acetyl L-Carnetine, and L-Carnetine with Acetyl L-Carnetine (300mg/Kg) as gavage for 30 days. The lipid per-oxidation, the serum glucose, the lipid profile, and the liver enzymes were measured at the end of the experiment. Data was analyzed using one-way ANOVA followed by Tukey complementary test.   

Findings: The fasting blood concentration, triglyceride, cholesterol, creatinine, the serum liver enzymes, and the level of the liver tissue malondialdehyde significantly decreased in treatment diabetic group than diabetic group without any treatment, while HDL level increased as well (p<0.05). The brain tissue malondialdehyde and the serum HDL decreased and increased due to the administration of Acetyl L-Carnitine, respectively. Nevertheless, it affected no other parameter significantly. The positive effects of L-Carnitine were reduced by the administration of Acetyl L-Carnitin with L-Carnitine. 

Conclusion: The administration of L-Carnitine further reduces the secondary side-effects of diabetes than Acetyl L-Carnitine. In addition, simultaneous administration of the materials is not recommended.

Keywords: Diabetes Mellitus [http://www.ncbi.nlm.nih.gov/mesh/68003920], L-Carnitine [http://www.ncbi.nlm.nih.gov/mesh/68002331], Acetyl L-Carnitine [http://www.ncbi.nlm.nih.gov/mesh/68000108], Rats [http://www.ncbi.nlm.nih.gov/mesh/68051381]
Full-Text [PDF 426 kb]   (794 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2015/10/25 | Accepted: 2016/05/10 | Published: 2016/05/24
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DOI: 10.18869/acadpub.hms.22.3.229


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Hajinezhad M, Hajian S, Saghayei S, Samzadeh-Kermani A, Nabavi R. Comparison the Protective Effects of L-Carnitine and Acetyl L-Carnitine on Blood Glucose and Lipid Peroxidation Level in Diabetic Rats. Horizon Med Sci . 2016; 22 (3) :229-235
URL: http://hms.gmu.ac.ir/article-1-2342-en.html
Volume 22, Number 3 (summer 2016) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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