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Horizon Med Sci 2016, 22(2): 89-94 Back to browse issues page
Comparison the Effects of Intravenous Hydrocortisone and Dexamethasone before Extubation on Laryngospasm, Cough and Stridor after General Anesthesia
A. Hamzei1, M. Basiri Mogadam2, M. Yousef zadeh Ghoochani3, M. Heidary Karizaki *4
1- Anesthesia & Operating Room Department, Paramedical Faculty, Gonabad University of Medical Sciences, Gonabad, Iran
2- “Social Development & Health Promotion Research Center” and “Nursing Department, Nursing & Midwifery Faculty”, Gonabad University of Medical Sciences, Gonabad, Iran
3- Anesthesia & Operating Room Department, Paramedical Faculty, Mashhad University of Medical Sciences, Mashhad, Iran
4- Nursing & Midwifery Department, Nursing & Midwifery Faculty, Gonabad University of Medical Sciences, Gonabad, Iran , Heidarykm1@mums.ac.ir
Abstract:   (1606 Views)

Aims: After tracheal extubation, following the patient’ waking up from general anesthesia, respiratory physiological responses are with symptoms such as cough, laryngospasm, and stridor. Different medications are used to prevent these complications. The aim of this study was to compare the effects of intravenous hydrocortisone and dexamethasone on the respiratory side-effects before tracheal extubation. 
Materials & Methods: In this two-blinded clinical trial, 108 patients candidate for orthopedic surgery, general surgery, and urology by general anesthesia hospitalized in Shahid Hashemi Nezhad and Bidaxt 15th Khordad hospitals were studied in Mashhad, Iran, in 2015. The subjects were selected via available sampling method. Randomized assignment was done by BBR. The first and the second groups received 100mg hydrocortisone and 8mg dexamethasone 30 minutes before tracheal extubation as one intravenous dosing, respectively. Individual information and clinical status were recorded based on the diagnoses by an anesthesiologist. Data was analyzed by SPSS 13 software using Chi-square, independent T, and Mann-Whitney tests. 
Findings: There was no significant difference between dexamethasone and hydrocortisone groups in the frequencies of cough, laryngospasm, and stridor (p>0.05). There were significant differences between the mean weights of patients with laryngospasm (p=0.03), cough (p=0.002), and stridor (p=0.001) and the patients without such symptoms. There was no significant difference in gender between patients with stridor and laryngospasm and other patients without such symptoms (p>0.05), excluding patients with cough (p=0.003). 
Conclusion: The effects of hydrocortisone and dexamethasone are similar on laryngospasm, cough, and stridor after tracheal extubation.

Keywords: Laryngismus, Cough, Respiratory Sounds, Hydrocortisone, Dexamethasone
Full-Text [PDF 437 kb]   (824 Downloads)    
Type of Study: Original | Subject: Anesthesiology
Received: 2015/08/2 | Accepted: 2016/02/10 | Published: 2016/02/17
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DOI: 10.18869/acadpub.hms.22.2.89


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Hamzei A, Basiri Mogadam M, Yousef zadeh Ghoochani M, Heidary Karizaki M. Comparison the Effects of Intravenous Hydrocortisone and Dexamethasone before Extubation on Laryngospasm, Cough and Stridor after General Anesthesia. Horizon Med Sci . 2016; 22 (2) :89-94
URL: http://hms.gmu.ac.ir/article-1-2277-en.html
Volume 22, Number 2 (Spring 2016) Back to browse issues page
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