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:: Volume 22, Number 2 (Spring 2016) ::
Horizon Med Sci 2016, 22(2): 151-158 Back to browse issues page
Analgesic Effect of Alcoholic Extract of Morus alba L. Leaf on Male Rats
Mojgan Mohammadifar1, Omid Reza Tamtaji2, Mohammad Behnam3, Mohsen Taghizadeh4, Sayyed Alireza Talaei *5
1- B.SC Biochemistry and Nutrition in Metabolic Diseases Research Center,
2- B.SC Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
3- Student Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
4- Associate Professor Biochemistry and Nutrition in Metabolic Diseases Research Center,
5- PhD Student Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran , talaeizavareh@gmail.com
Abstract:   (1015 Views)

Aims: As effective herbal materials, flavonoids and the phenolic compounds are with anti-pain and anti-inflammatory effects. Based on the studies, there is a huge amount of polyphenols and flavonoids in the leaves of Morus alba L. Therefore, the aim of this study was to investigate the anti-pain effects of alcoholic extract of the leaves of Morus alba L. on the rats.

Materials & Methods: In the experimental study, 32 male Wistar rats were divided into 4 groups including control group and groups receiving 100, 200, and 400mg/kg alcoholic extract of the leaves of Morus alba L. There was 4-week daily extract gavage. The anti-pain effect of the extract was investigated through thermal hyperalgesia, writhing, tail flick, and formalin tests. Data was analyzed by SPSS 16 software using one-way ANOVA and Tukey’s post-hoc tests.

Findings: Daily use of 100, 200, and 400mg/kg of alcoholic extract of the leaves of Morus alba L. for 4 weeks led to significant increases in the mean foot withdrawal latency (p<0.001) and mean tail withdrawal latency (p<0.001) and significant reductions in the percentage of abdominal constriction (p<0.001) and pain feeling in both acute (p<0.05) and chronic (p<0.01) phases of formalin test than control group. Nevertheless, the effect of 200mg/kg dose was higher than the other doses.    

Conclusion: Oral consumption of the alcoholic extract of the leaves of Morus alba L. leads to a reduction in pain feeling in the rats. In addition, the anti-pain effect of 200mg/kg dose is higher than other doses.

Keywords: Analgesics, Morus, Rats
Full-Text [PDF 537 kb]   (573 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2015/07/20 | Accepted: 2016/02/10 | Published: 2016/02/17
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DOI: 10.18869/acadpub.hms.22.2.151


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Mohammadifar M, Tamtaji O R, Behnam M, Taghizadeh M, Talaei S A. Analgesic Effect of Alcoholic Extract of Morus alba L. Leaf on Male Rats. Horizon Med Sci . 2016; 22 (2) :151-158
URL: http://hms.gmu.ac.ir/article-1-2263-en.html
Volume 22, Number 2 (Spring 2016) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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