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Background and Aim: Recent developments in anesthesia have brought human beings to realize analgesia as the main objectives of painlessness, so they try to find the simplest method and the most economical drug with less side effects for it. This research has been done to compare the effects of three drugs, epinephrine, fentanyl and sufentanil with lidocaine on spinal anesthesia to find the best drug. Materials and Methods: This is a clinical trial and the samples were 50-60 year men reffering to Gonabad 15 khordad hospital, for inguinal hernia operation 120 patients were divided into 3 groups randomly each group consists of 40 men. In one group (E) 0.2 mg epinephrine and in other group (F) 25 µg fentanyl and in the 3rd group (S) 2.5 µg sufentanil with 100 mg lidocaine 5% were used for spinal anesthesia. A check list and a questionaire were used for data collection, and then the data were analyzed by computer softwares and chi-square and ANOVA. The p value < 0.05 was considered significant. Results: The mean duration of analgesia in group E was 82.1±15.7 minutes and in group F was 99.37±18.61 minutes and in group S, it was 153.62±26.62 minutes. So, there was a significant difference between the three groups regarding the duration of analgesia (F=121.1, P<0.001). In group F the occurance of hypotention was %15, bradycardia was %10 and vomiting and nausea was %7.5 but in group F, it was %37.5, %27.5 and %10 and in group S, it was %40, %32.5 and %15, respectively that was not significant. Conclusion: The length of analgesia in spinal anesthesia with sufentanil was more than fentanyl and with fentanyl It was more than epinephrine and there was a significant difference, but it was not significant regarding to side effects like hypotention, bradycardia,vomiting and nausea.

Keywords: Epinephrine; Fentanyl; Sufentanil; Spinal anesthesia; Lidocaine

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