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:: Volume 22, Number 2 (Spring 2016) ::
Horizon Med Sci 2016, 22(2): 103-109 Back to browse issues page
Comparison of Oral and Vaginal Prescription of Misoprostol in Labor Induction of Post-Term Pregnancies
Masome Rezaie1, Faribs Seyedoshohadaei2, Morteza Nayebi3
1- Assistant Professor Obstetrics & Gynecology Department, Medicine Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- associate professor Obstetrics & Gynecology Department, Medicine Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Internal medicine Tohid Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran
Abstract:   (1117 Views)

Aims: There is a considerable increase in the maternal and infancy mortality and side-effects in accordance with higher pregnancy ages. Due to such a risk, it is nedded to statrt the labor induction from week 40. Misoprostol is one of the medications used in such conitions. The aim of this study was to compare the effects of oral misoprostol and vaginal misoprostol in the labor induction in the prolonged pregnancy. 

Materials & Methods: In the two-blinded random climical trial, 180 pregnant women with more than 40 weeks gestational age referred to the labor ward of Sanadaj Besat Hospital were studied in 2013-2014. The samples were selected via randomized blocking sampling method. Through sixtuple random blocking method, the subjects were divided into three groups including 50μg oral misoprostol, 100μg oral misoprostol, and 25μg vaginal misoprostol. Having been recorded on a checklist, data was analyzed by SPSS 18 software using one-way ANOVA, Chi-square, and Fisher’s exact tests.

Findings: There were significant differences between the mean 1st minute Apgar score and the medication consumption dose in the groups (p=0.0001). There were no differences between the groups in the mean 5th minute Apgar score, induction frequency, induction times, mode of delivery, and its side-effects (p>0.05). Nevertheless, there were significant differences in fetal distress frequency and the infant hospitalization (p<0.05). There were no significant differences in the mean interval between misoprostrol consumption and the delivery time between the groups (p=0.28).

Conclusion: Considering the labor induction time and maternal and infancy outcomes, administration of 100&mu;g oral misoprostrol in the prolonged pregnant women is more useful than 50&mu;g oral misoprostrol and 25&mu;g vaginal misoprostrol.

Keywords: Labor, Induced, Misoprostol, Pregnancy, Prolonged
Full-Text [PDF 459 kb]   (590 Downloads)    
Type of Study: Original | Subject: Obstetrics and Gynecology
Received: 2015/06/16 | Accepted: 2015/12/20 | Published: 2016/02/17



DOI: 10.18869/acadpub.hms.22.2.103


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Rezaie M, Seyedoshohadaei F, Nayebi M. Comparison of Oral and Vaginal Prescription of Misoprostol in Labor Induction of Post-Term Pregnancies. Horizon Med Sci . 2016; 22 (2) :103-109
URL: http://hms.gmu.ac.ir/article-1-2233-en.html
Volume 22, Number 2 (Spring 2016) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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