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:: Volume 21, Number 3 (Fall 2015) ::
Horizon Med Sci 2015, 21(3): 169-174 Back to browse issues page
Effect of Hydroalcoholic Extract of Kelussia odoratissima Mozaffarian on Uterus Contractions of Mature Rats
lobat jafarzadeh1, Roya Habibian2, Mahmood Rafieian Kopaei *3, Zohre Mohammadzade4
1- Associate professor, Department of Obstetrics and Gynecology, Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord Obstetrics and Gynecology Department, Shahrekord University of Medical Science, Shahrekord, Iran
2- Infectious Disease Department, Medicine Faculty, Shahrekord University of Medical Science, Shahrekord, Iran
3- Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran , rafieian@yahoo.com
4- Medical Sciences Department, Faculty of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran
Abstract:   (1329 Views)

Aims: Kelussia odoratissima is a plant from Umbelliferae family that has nutritional and pharmacological properties. The antispasmodic effect of this plant has been mentioned in Iranian traditional medicine. The aim of study was to assess the effect of alcoholic extract of Kelussia odoratissima on uterus contractions of adult rats. Materials & Methods: In this experimental study, 16 adult female Wistar rats were studied and were randomly divided into two groups (each consisted of 8 rats) receiver of Tyrod solution (first group) and receiver of Dejalon solution (second group) groups. A 10-15mm sample of uterus smooth muscle were placed in an organ bath containing Tyrod or Dejalon solution (10ml), and contractions were recorded with Isometric method after inducing with KCl and Oxytocin. The 0.125, 0.25 and 0.5mg/ml final concentrations of the alcoholic extract of Kelussia odoratissima was added to the organ bath. Data were statistically analyzed by SPSS 17 software using repeated measures ANOVA. Findings: The alcoholic extract of Kelussia odoratissima significantly decreased the KCl-induced (p<0.001) and Oxytocin-induced (p<0.002) contractions in a concentration dependent manner. Conclusion: The alcoholic extract of Kelussia odoratissima inhibits the contractions of adult rat uterus in a concentration dependent manner. Keywords Kelussia odoratissima [Not in MeSH] Uterine Contraction [http://www.ncbi.nlm.nih.gov/mesh/68014590] Rats [http://www.ncbi.nlm.nih.gov/mesh/68051381] Potassium Chloride [http://www.ncbi.nlm.nih.gov/mesh/68011189] Oxytocin [http://www.ncbi.nlm.nih.gov/mesh/68010121]

Keywords: Kelussia odoratissima], Uterine Contraction [http://www.ncbi.nlm.nih.gov/mesh/68014590], Rats [http://www.ncbi.nlm.nih.gov/mesh/68051381], Potassium Chloride [http://www.ncbi.nlm.nih.gov/mesh/68011189]Oxytocin [http://www.ncbi.nlm.nih.gov/mesh/68010121]
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Type of Study: Original | Subject: Obstetrics and Gynecology
Received: 2015/05/1 | Accepted: 2015/07/7 | Published: 2015/08/19
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DOI: 10.18869/acadpub.hms.21.3.169


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jafarzadeh L, Habibian R, Rafieian Kopaei M, Mohammadzade Z. Effect of Hydroalcoholic Extract of Kelussia odoratissima Mozaffarian on Uterus Contractions of Mature Rats. Horizon Med Sci . 2015; 21 (3) :169-174
URL: http://hms.gmu.ac.ir/article-1-2198-en.html
Volume 21, Number 3 (Fall 2015) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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