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:: Volume 21, Number 3 (Fall 2015) ::
Horizon Med Sci 2015, 21(3): 163-168 Back to browse issues page
Effect of Interaction of Age and Changing in Visual Experience During Critical Period of Brain Development on Expression of Melatonin Receptors in Rat’s Hippocampus
Sayyed Alireza Talaei 1, Mojgan Mohammadifar2, Abolfazl Azami3, Mahmoud Salami4
1- Student Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran , talaei@kaums.ac.ir
2- Student Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
3- Assistant Professor Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
4- Professor Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
Abstract:   (1134 Views)

Aims: Melatonin modulates the function of nervous system and its secretion is dependent to circadian rhythms and visual signals. The melatonin receptors are founded in many areas of the brain. During critical period of the brain development, the structure of mammals’ brain is intensely affected by peripheral sensory signals. The aim of this study was to evaluate the effect of interaction of age and visual deprivation during critical period of brain development on melatonin receptors expression in rats’ hippocampus. Materials & Methods: This experimental study was carried on 2 groups (n=36) of male Wistar rats kept in standard 12 hour light/dark condition (Light Reared-LR) or in complete darkness (Dark Reared-DR). The rats of each groups, were introduced into the experiments at 2, 4 and 6 weeks old of age. Expression of mRNA of both melatonin receptors, MT1 and MT2, in the hippocampus was evaluated by RT-PCR and using Western Blot technique, protein expression of those receptors was investigated. Data were analyzed by one-way ANOVA with Tukey post hoc tests. Findings: The relative expression of mRNA and protein of MT1 and MT2 receptors increased about 36% in the LR animals from 2 to 6 weeks old of age (p<0.001). The visual deprivation caused a decrease of 35% and 50% in expression of MT1 and MT2 from 2 to 6 weeks old of age, respectively (p<0.001 for both comparison). Conclusion: The relative expression of both melatonin receptors in rats’ hippocampus increases across aging during critical period of brain development and visual deprivation reverses the pattern of melatonin receptors expression.

Keywords: Melatonin [http://www.ncbi.nlm.nih.gov/mesh/68008550], Receptor, Melatonin, MT2 [http://www.ncbi.nlm.nih.gov/mesh/68044123], Receptor, Melatonin, MT1 [http://www.ncbi.nlm.nih.gov/mesh/ 68044122], Critical Period (Psychology) [http://www.ncbi.nlm.nih.gov/mesh
Full-Text [PDF 608 kb]   (557 Downloads)    
Type of Study: Original | Subject: Basic Medical Science
Received: 2015/03/6 | Accepted: 2015/07/7 | Published: 2015/08/19
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DOI: 10.18869/acadpub.hms.21.3.163


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Talaei S A, Mohammadifar M, Azami A, Salami M. Effect of Interaction of Age and Changing in Visual Experience During Critical Period of Brain Development on Expression of Melatonin Receptors in Rat’s Hippocampus. Horizon Med Sci . 2015; 21 (3) :163-168
URL: http://hms.gmu.ac.ir/article-1-2171-en.html
Volume 21, Number 3 (Fall 2015) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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