Abstract Aims: Increased levels of CRP, uric acid and total bilirubin increase the risk of coronary artery disease. The aim of this study was to investigate the effects of selected aerobic training on CRP, uric acid and total bilirubin in sedentary elderly women. Materials & Methods: In this semi-experimental study, in 2014, which was done in Mashhad, 21 sedentary and healthy women with range of 60-70 years old were selected using available and purposive sampling method. They were randomly divided into two groups experimental (n=11) and control (n=10). The 8 weeks of aerobic training (3 times a week, 45-60 minutes per session, with intensity of 50-70 percent of reserve heart rate) were performed. Blood samples were taken at baseline and at the end of the study. Data were analyzed using paired and independent T tests in SPSS 20 software. Findings: Body weight (p=0.001), BMI (p=0.01), body fat percent (p=0.02), CRP levels (p=0.01) and uric acid (p=0.001) were decreased at the end of training compared with the beginning of aerobic training significantly in the experimental group. Moreover, a significant difference was observed between experimental and control groups according to weight (p<0.05). Conclusion: The aerobic training has positive effects on the new biomarker of cardiovascular indicators and aerobic training can prevent the incidence of atherosclerosis diseases.