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Horizon Med Sci 2015, 21(1): 31-36 Back to browse issues page
Effect of Hydroalcoholic Extract of Prosopis farcta Pod on Liver Histopathology and Malondialdehyde Level in Streptozotocin Diabetic Rats
Mohammadreza Hajinezhad *1, Sedigheh Esmaeel Zadeh Bahabadi2, Hamidreza Miri3, Ida Davari4, Mousa Darvish Sargazi5
1- PhD Basic Sciences Department, Veterinary Medicine Faculty, University of Zabol, Zabol, Iran , hajinezhad@gmail.com
2- PhD Biology Department, Basic Sciences Faculty, University of Zabol, Zabol, Iran
3- PhD Basic Sciences Department, Medicine Faculty, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran
4- PhD Pathobiology Department, Veterinary Medicine Faculty, University of Zabol, Zabol, Iran
5- BSc Biology Department, Basic Sciences Faculty, University of Zabol, Zabol, Iran
Abstract:   (1289 Views)

Aims: Diabetes is a common endocrine disorder that can lead to hyperglycemia and hyperlipidemia. The aim of this study was to investigate the effect of hydroalcoholic extract of pod Prosopis fracta, on liver histopathology and tissue level of malondialdehyde (MDA) in streptozotocin-induced diabetic rats. Materials & Methods: 45 male Wistar rats (200-300g) were divided into 3 groups control, diabetic and Prosopis farcta extract treated diabetic. Type 1 diabetes was induced in by injection of streptozotocin (42mg/kg). One week after diabetes induction, Prosopis farcta extract (300mg/kg of body weight) was administered to treated diabetic group by gavage for 30 days. Hepatic histological changes were assessed with Hematoxylin-Eosin staining under light microscopy. The liver concentration of MDA was determined as thiobarbituric acid reactive substances (TBARS). The obtained data were statistically analyzed using Students T and Mann-Whitney rank sum tests. Findings: Administration of Prosopis fracta extract decreased the concentration of malondialdehyde in liver tissue of treated diabetic group in comparison to diabetic group significantly (p<0.05). Inflation and vacuolation of hepatocytes were observed with disarrangement of hepatic cords and sinusoidal narrowing. All previous signs were improved in Prosopis fracta treated group. Conclusion: Hydro-alcoholic extract of Prosopis fracta pod can reduce the level of malondialdehyde as a marker of lipid peroxidation in liver and prevent the histopathological changes of liver associated with diabetes.

Keywords: Prosopis [http://www.ncbi.nlm.nih.gov/mesh/68029862], Pathology [http://www.ncbi.nlm.nih.gov/mesh/68010336], Liver [http://www.ncbi.nlm.nih.gov/mesh/68008099], Diabetes Mellitus [http://www.ncbi.nlm.nih.gov/mesh/68003920]
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Type of Study: Applicable | Subject: Basic Medical Science
Received: 2014/11/12 | Accepted: 2015/03/17 | Published: 2015/04/28
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DOI: 10.18869/acadpub.hms.21.1.31


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Hajinezhad M, Esmaeel Zadeh Bahabadi S, Miri H, Davari I, Darvish Sargazi M. Effect of Hydroalcoholic Extract of Prosopis farcta Pod on Liver Histopathology and Malondialdehyde Level in Streptozotocin Diabetic Rats. Horizon Med Sci . 2015; 21 (1) :31-36
URL: http://hms.gmu.ac.ir/article-1-2087-en.html
Volume 21, Number 1 (Spring 2015) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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