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Horizon Med Sci 2015, 21(1): 7-12 Back to browse issues page
Comparison of the Effect of Edible Citrullus colocynthis Fruit Powder with Metformin on the Level of Blood Glucose in Streptozotocin-Induced Diabetic Male Rats
Nasim Mojaz Dalfardi1, Hamide Ghodrati Azadi 2, Behrooz Fathi Hafshjani1
1- PhD Basic Sciences Department, Veterinary Medicine Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
2- PhD Basic Sciences Department, Veterinary Medicine Faculty, Ferdowsi University of Mashhad, Mashhad, Iran , ghodrati@um.ac.ir
Abstract:   (1376 Views)

Aims: Diabetes is one of the metabolic diseases. According to side effects of medication and high costs of treatments, medical plants are of attention. This study was done to compare the anti-diabetic effect of Citrullus colocynthis fruit powder with metformin on blood glucose level. Materials & Methods: 32 mature male rats with an average weight of 250-300gr were divided into four groups a negative control (normal diet), a positive control (distilled water), a sham (14 mg/kg metformin) and a treatment (50mg/kg Citrullus colocynthis). Type 2 diabetes induced by intraperitoneal injection of 60mg/kg of Streptozotocin (two times, with 48h interval) in all except the negative control group. These solutions regularly administrated by using oral gavage for 6 weeks. After 12 hours of fasting, before the first and after the last doses, the blood glucose was measured via the tail vein. Statistical analysis was performed in SPSS 18 software by one way ANOVA with repeated measurement tests. Findings: The decreasing level of glucose between metformin and Citrullus colocynthis groups was significant in day 28 (p<0.05), But it was not significant in day 42. Conclusion: Metformin can be replaced by Citrullus colocynthis in reducing blood glucose.

Keywords: Diabetes Mellitus [http://www.ncbi.nlm.nih.gov/mesh/68003920], Citrullus colocynthis [http://www.ncbi.nlm.nih.gov/mesh/68065986], Metformin [http://www.ncbi.nlm.nih.gov/mesh/68008687], Streptozocin [http://www.ncbi.nlm.nih.gov/mesh/68013311], Blood Glucose
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Type of Study: Original | Subject: Basic Medical Science
Received: 2014/10/31 | Accepted: 2015/01/31 | Published: 2015/03/17
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DOI: 10.18869/acadpub.hms.21.1.7


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Mojaz Dalfardi N, Ghodrati Azadi H, Fathi Hafshjani B. Comparison of the Effect of Edible Citrullus colocynthis Fruit Powder with Metformin on the Level of Blood Glucose in Streptozotocin-Induced Diabetic Male Rats. Horizon Med Sci . 2015; 21 (1) :7-12
URL: http://hms.gmu.ac.ir/article-1-2082-en.html
Volume 21, Number 1 (Spring 2015) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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